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Expression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patients

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dc.contributor.authorChoi, Young Jin-
dc.contributor.authorChoi, Yoon La-
dc.contributor.authorCho, Eun Yoon-
dc.contributor.authorShin, Young Kee-
dc.contributor.authorKong, Gu-
dc.contributor.authorKim, Jee Soo-
dc.contributor.authorYang, Jung-Hyun-
dc.contributor.authorNam, Seok Jin-
dc.contributor.authorKim, Jung Han-
dc.contributor.authorLee, Jeong Eon-
dc.contributor.authorLee, Sang Jin-
dc.contributor.authorHwang, Yu Kyeong-
dc.contributor.authorSung, Ki Woong-
dc.date.accessioned2013-01-23T02:29:29Z-
dc.date.available2013-01-23T02:29:29Z-
dc.date.issued2009-01-
dc.identifier.citationBREAST CANCER RESEARCH AND TREATMENT, Vol.113, No.1, pp.83-93ko_KR
dc.identifier.issn0167-6806-
dc.identifier.urihttps://hdl.handle.net/10371/81017-
dc.description.abstractPurpose Abnormal expression of the cell cycle regulatory protein Bmi-1 has been studied in breast cancer, but the clinical relevance has not been fully elucidated. We studied the expression of Bmi-1 protein in breast cancer patients to define its clinical significance in breast cancer. Experimental Design Tissue microarrays were performed to evaluate the expression of Bmi-1 by immunohistochemistry in tumor tissues from 960 patients with stage I-III breast cancer. We assessed the relationship between the expression of Bmi-1 and pathologic prognostic indices as well as clinical long-term follow up outcome. Results Bmi-1 was expressed in 53.2% of breast cancer patients by immunohistochemistry, and the expression of Bmi-1 was significantly correlated with favorable prognostic indices at diagnosis. In univariate analysis, patients with Bmi-1 expression showed favorable relapse-free survival (88.6 +/- A 2.7% vs. 72.3 +/- A 4.3%, P = 0.041) and favorable overall survival (93.5 +/- A 2.2% vs. 82.6 +/- A 3.5%, P < 0.001) than patients without Bmi-1 expression. According to multivariate analyses, Bmi-1 expression was identified as independent prognostic factor for overall survival with a statistical significance (hazard ratio of Bmi-1 (-) patients compared to Bmi-1 (+) patients, 1.744; 95% CI, 1.013-3.003; P = 0.045). This correlation of Bmi-1 expression with favorable overall survival was maintained in patients underwent uniform chemotherapy, regardless of undergoing adjuvant chemotherapy. In a subset analysis according to ER status, Bmi-1 expression associated with favorable overall survival only in ER-positive patients. Conclusions Bmi-1 expression assessed with Immunohistochemistry may be associated with favorable overall survival in breast cancer patients, especially in patients with ER-positive breast cancer.ko_KR
dc.language.isoenko_KR
dc.publisherSpringer Verlagko_KR
dc.subjectBmi-1ko_KR
dc.subjectPrognostic markersko_KR
dc.subjectImmunohistochemistryko_KR
dc.subjectBreast cancerko_KR
dc.subjectCell cycle regulatorko_KR
dc.titleExpression of Bmi-1 protein in tumor tissues is associated with favorable prognosis in breast cancer patientsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor최영진-
dc.contributor.AlternativeAuthor최윤라-
dc.contributor.AlternativeAuthor조은윤-
dc.contributor.AlternativeAuthor신영기-
dc.contributor.AlternativeAuthor공구-
dc.contributor.AlternativeAuthor김지수-
dc.contributor.AlternativeAuthor양정현-
dc.contributor.AlternativeAuthor남석진-
dc.contributor.AlternativeAuthor김정한-
dc.contributor.AlternativeAuthor이정언-
dc.contributor.AlternativeAuthor이상진-
dc.contributor.AlternativeAuthor황유경-
dc.contributor.AlternativeAuthor성기웅-
dc.identifier.doi10.1007/s10549-008-9909-4-
dc.citation.journaltitleBREAST CANCER RESEARCH AND TREATMENT-
dc.description.tc17-
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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