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Influences of hyaluronic acid on the anticandidal activities of lysozyme and the peroxidase system

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dc.contributor.authorKang, J.-H.-
dc.contributor.authorKim, Y.-Y.-
dc.contributor.authorChang, J.-Y.-
dc.contributor.authorKho, Hong-Seop-
dc.date.accessioned2013-01-24T02:35:46Z-
dc.date.available2013-01-24T02:35:46Z-
dc.date.issued2011-
dc.identifier.citationOral Diseases; Vol.17, No.6, pp.577-583ko_KR
dc.identifier.issn1601-0825-
dc.identifier.urihttps://hdl.handle.net/10371/81060-
dc.description.abstractObjective: To investigate the fungistatic and fungicidal activity of hyaluronic acid (HA) and the influences of HA on the anticandidal activities of lysozyme and the peroxidase system. Materials and Methods: HA, hen egg-white lysozyme, and the bovine lactoperoxidase system were used. Candida albicans ATCC 10231, 18804, and 11006 strains were used in the experiments. The fungistatic activity of HA was determined by measuring the optical densities of the cultures. The candidacidal activity of HA and the influences of HA on the candidacidal activities of lysozyme and the peroxidase system were determined by comparing the numbers of colony-forming units. Results: Hyaluronic acid displayed inhibitory effects on the growth of C. albicans, and the inhibitory effects were proportional to HA concentration. HA did not have any measurable candidacidal activity. HA showed inhibitory effects on the candidacidal activities of lysozyme, and the peroxidase system that was proportional to HA concentration. HA at 1.0-2.0mgml -1 almost completely inhibited the candidacidal activities of lysozyme and the peroxidase system. Conclusions: Hyaluronic acid possesses fungistatic activity but no candidacidal activity. HA showed inhibitory effects on the candidacidal activities of lysozyme and the peroxidase system. ⓒ 2011 John Wiley & Sons A/S.ko_KR
dc.language.isoenko_KR
dc.publisherJohn Wiley & Sonsko_KR
dc.subjectAnticandidal activityko_KR
dc.subjectHyaluronic acidko_KR
dc.subjectPeroxidaseko_KR
dc.subjectLysozymeko_KR
dc.titleInfluences of hyaluronic acid on the anticandidal activities of lysozyme and the peroxidase systemko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor강정현-
dc.contributor.AlternativeAuthor김윤영-
dc.contributor.AlternativeAuthor장지연-
dc.contributor.AlternativeAuthor고홍섭-
dc.identifier.doi10.1111/j.1601-0825.2011.01807.x-
dc.citation.journaltitleOral Diseases-
dc.description.tc1-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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