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Pediatric infratentorial ependymoma: prognostic significance of anaplastic histology

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dc.contributor.authorPhi, Ji Hoon-
dc.contributor.authorWang, Kyu-Chang-
dc.contributor.authorPark, Sung-Hye-
dc.contributor.authorKim, Il Han-
dc.contributor.authorKim, In-One-
dc.contributor.authorPark, Kyung Duk-
dc.contributor.authorAhn, Hyo Seop-
dc.contributor.authorLee, Ji Yeoun-
dc.contributor.authorSon, Young-Je-
dc.contributor.authorKim, Seung-Ki-
dc.creator박성혜-
dc.date.accessioned2013-03-21T09:53:57Z-
dc.date.available2013-03-21T09:53:57Z-
dc.date.issued2012-02-
dc.identifier.citationJOURNAL OF NEUROONCOLOGY Vol.106 No.3, pp. 619-626-
dc.identifier.issn0167-594X-
dc.identifier.urihttps://hdl.handle.net/10371/81388-
dc.description.abstractPediatric infratentorial ependymomas are difficult to cure. Despite the availability of advanced therapeutic modalities for brain tumors, total surgical resection remains the most important prognostic factor. Recently, histological grade emerged as an independent prognostic factor for intracranial ependymoma. We retrospectively reviewed the treatment outcome of 33 pediatric patients with infratentorial ependymoma. Progression-free survival (PFS) and overall survival (OS) rates were calculated and relevant prognostic factors were analyzed. Fourteen patients (42%) were under the age of 3 at diagnosis. Gross total resection was achieved in 16 patients (49%). Anaplastic histology was found in 13 patients (39%). Adjuvant therapies were delayed until progression in 12 patients (36%). Actuarial PFS rates were 64% in the first year and 29% in the fifth year. Actuarial OS rates were 91% in the first year and 71% in the fifth year. On univariate analysis, brainstem invasion (P = 0.047), anaplastic histology (P = 0.004), higher mitotic count (P = 0.001), and higher Ki-67 index (P = 0.004) were significantly related to a shorter PFS. Gross total resection (P = 0.029) and a greater age at diagnosis (P = 0.033) were significantly related to a longer PFS. On multivariate analysis, anaplastic histology alone was significantly related to a shorter PFS (P = 0.023). Gross total resection (P = 0.039) was significantly related to a longer overall survival (OS) on multivariate analysis. Anaplastic histology and gross total resection were the most important clinical factors affecting PFS and OS, respectively. Anaplastic histology, mitotic count, and Ki-67 index can be used as universal and easily available prognostic parameters in infratentorial ependymomas.en
dc.language.isoenen
dc.publisherSpringeren
dc.subject복합학en
dc.subjectEpendymoma-
dc.subjectChildren-
dc.subjectPrognosis-
dc.subjectSurvival-
dc.subjectAnaplastic histology-
dc.titlePediatric infratentorial ependymoma: prognostic significance of anaplastic histologyen
dc.typeArticle-
dc.contributor.AlternativeAuthor피지훈-
dc.contributor.AlternativeAuthor왕규창-
dc.contributor.AlternativeAuthor박성혜-
dc.contributor.AlternativeAuthor김일한-
dc.contributor.AlternativeAuthor김인원-
dc.contributor.AlternativeAuthor박경덕-
dc.contributor.AlternativeAuthor안효섭-
dc.contributor.AlternativeAuthor이지연-
dc.contributor.AlternativeAuthor손영제-
dc.contributor.AlternativeAuthor김승기-
dc.identifier.doi10.1007/s11060-011-0699-x-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000027894/1-
dc.description.srndSEQ:1-
dc.description.srndPERF_CD:SNU2012-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000027894-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A075873-
dc.description.srndDEPT_CD:801-
dc.description.srndCITE_RATE:3.214-
dc.description.srndFILENAME:Phi-2012-Pediatric infratento.pdf-
dc.description.srndDEPT_NM:의학과-
dc.description.srndEMAIL:shparknp@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2012-01/102/0000027894/1-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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