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Directing the differentiation of human dental follicle cells into cementoblasts and/or osteoblasts by a combination of HERS and pulp cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Hyun-Sung | - |
dc.contributor.author | Lee, Dong-Seol | - |
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Park, Su-Jin | - |
dc.contributor.author | Lee, Gene | - |
dc.contributor.author | Seo, Byoung-Moo | - |
dc.contributor.author | Ko, Jea Seung | - |
dc.contributor.author | Park, Joo-Cheol | - |
dc.creator | 박주철 | - |
dc.date.accessioned | 2013-03-22T01:17:58Z | - |
dc.date.available | 2013-03-22T01:17:58Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.citation | JOURNAL OF MOLECULAR HISTOLOGY Vol.42 No.42, pp. 227-235 | - |
dc.identifier.issn | 1567-2379 | - |
dc.identifier.uri | https://hdl.handle.net/10371/81392 | - |
dc.description.abstract | It is known that the dental follicle (DF) consists
of progenitor cells that give rise to the cementum, periodontal ligament, and alveolar bone; but little information is available about the regulation of DF cell differentiation into either cementogenic or osteogenic cell lineages for the regeneration of diseased periodontal tissue. Here, we investigated the roles of DF, Hertwigs epithelial root sheath (HERS), and pulp cells in the cementum and during alveolar bone formation. We cultured these cells; transplanted them alone or in combination into immunocompromised mice; and observed their effects at 6 and 12 weeks. Histological and immunohistochemical results revealed that DF cells formed cementum-like tissues with immunoreactivity to cementum-derived attached protein, bone sialoprotein, type I collagen, and alkaline phosphatase. In addition, HERS cells played a role in the induction and maturation of cementum-like tissues formed by DF cells. In contrast, implants of DF cells in the presence of pulp cells led to the formation of bone-like tissues. | - |
dc.language.iso | en | en |
dc.publisher | SPRINGER | en |
dc.subject | 복합학 | en |
dc.subject | Dental follicle cell | - |
dc.subject | Pulp cell | - |
dc.subject | HERS | - |
dc.subject | Cementum | - |
dc.subject | Alveolar bone | - |
dc.title | Directing the differentiation of human dental follicle cells into cementoblasts and/or osteoblasts by a combination of HERS and pulp cells | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이동설 | - |
dc.contributor.AlternativeAuthor | 이지현 | - |
dc.contributor.AlternativeAuthor | 박수진 | - |
dc.contributor.AlternativeAuthor | 이진 | - |
dc.contributor.AlternativeAuthor | 서병무 | - |
dc.contributor.AlternativeAuthor | 고제승 | - |
dc.contributor.AlternativeAuthor | 박주철 | - |
dc.contributor.AlternativeAuthor | 정현성 | - |
dc.identifier.doi | 10.1007/s10735-011-9327-5 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000042428/3 | - |
dc.description.srnd | SEQ:3 | - |
dc.description.srnd | PERF_CD:SNU2011-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000042428 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A077448 | - |
dc.description.srnd | DEPT_CD:861 | - |
dc.description.srnd | CITE_RATE:1.484 | - |
dc.description.srnd | FILENAME:Directing follilce-CR.pdf | - |
dc.description.srnd | DEPT_NM:치의학과 | - |
dc.description.srnd | EMAIL:jcapark@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2011-01/102/0000042428/3 | - |
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