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TGF-β1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27Kip1 CDK inhibitor in hepatoma cells replated on fibronectin
DC Field | Value | Language |
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dc.contributor.author | Kim, Hwang-Phil | - |
dc.contributor.author | Kim, Tai-Young | - |
dc.contributor.author | Lee, Mi-Sook | - |
dc.contributor.author | Jong, Hyun-Soon | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.creator | 이정원 | - |
dc.date.accessioned | 2013-04-16T07:52:01Z | - |
dc.date.available | 2013-04-16T07:52:01Z | - |
dc.date.issued | 2005-03 | - |
dc.identifier.citation | Biochimica et Biophysica Acta - Molecular Cell Research, Vol.1743 No.1-2, pp.151-161 | - |
dc.identifier.issn | 0167-4889 | - |
dc.identifier.other | 4014 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82046 | - |
dc.description.abstract | Integrin-mediated cell adhesion transduces signals to regulate actin cytoskeleton and cell proliferation. While understanding how integrin signals cross-talk with the TGF-beta 1 pathways, we observed lamellipodia formation and cyclin regulation in Hep3B cells, following TGF-beta 1 treatment. To answer if integrin signaling via actin organization might regulate cell cycle progression after TGF-beta 1 treatment, we analyzed cross-talk between the two receptor-mediated pathways in hepatoma cells on specific ECMs. We found that basal and TGF-beta 1-mediated activation of c-Src and Rac 1, expression of cyclins E and A, and suppression of p27(Kip1) were significant in cells replated on fibronectin, but not in cells on collagen 1, indicating a different integrin-mediated cellular response to TGF-beta 1 I treatment. Levels of tyrosine phosphorylation and actin-enriched lamellopodia on fibronectin were also more prominent than in cells on collagen I. Studies using pharmacological inhibitors or transient transfections revealed that the preferential TGF-beta 1 effects in cells on fibronectin required c-Src family kinase activity. These observations suggest that a specific cross-talk between TGF-beta 1 and fibronectin-binding integrin signal pathways leads to the activation of c-Src/Rac1/actin-organization, leading to changes in cell cycle regulator levels in hepatoma cells. Therefore, this study represents another mechanism to regulate cell cycle regulators when integrin signaling is collaborative with TGF-beta 1 pathways. (c) 2004 Elsevier B.V. All rights reserved. | - |
dc.language.iso | en | en |
dc.publisher | ELSEVIER | en |
dc.subject | integrin | - |
dc.subject | TGF-beta 1 | - |
dc.subject | cyclin | - |
dc.subject | signal cross-talk | - |
dc.subject | c-Src | - |
dc.subject | Rac1 | - |
dc.title | TGF-β1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27Kip1 CDK inhibitor in hepatoma cells replated on fibronectin | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1016/j.bbamcr.2004.09.014 | - |
dc.citation.journaltitle | Biochimica et Biophysica Acta - Molecular Cell Research | - |
dc.identifier.scopusid | 2-s2.0-17844380007 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2005-01/102/0000003910/2 | - |
dc.description.srnd | SEQ:2 | - |
dc.description.srnd | PERF_CD:SNU2005-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000003910 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A078142 | - |
dc.description.srnd | DEPT_CD:375 | - |
dc.description.srnd | CITE_RATE:4.844 | - |
dc.description.srnd | FILENAME:26HPKim_BBA.pdf | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:jwl@snu.ac.kr | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 161 | - |
dc.citation.number | 1-2 | - |
dc.citation.startpage | 151 | - |
dc.citation.volume | 1743 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0167488904002319?via%3Dihub | - |
dc.identifier.sci | 000228101100017 | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.identifier.srnd | 2005-01/102/0000003910/2 | - |
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