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Modulation of signaling between TM4SF5 and integrins in tumor microenvironment

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dc.contributor.authorLee, Sin-Ae-
dc.contributor.authorPark, Ki Hun-
dc.contributor.authorLee, Jung Weon-
dc.creator이정원-
dc.date.accessioned2013-04-16T07:54:04Z-
dc.date.available2013-04-16T07:54:04Z-
dc.date.issued2011-01-
dc.identifier.citationFRONTIERS IN BIOSCIENCE-LANDMARK Vol.16 No.5, pp. 1752-1758-
dc.identifier.issn1093-9946-
dc.identifier.urihttps://hdl.handle.net/10371/82066-
dc.description.abstractTM4SF5 is a transmembrane glycoprotein of the
transmembrane 4 L six family, a branch of the tetraspanin
family and highly expressed in many types of cancers.
TM4SF5 induces epithelial-mesenchymal transition (EMT)
by morphological changes resulting from inactivation of
RhoA mediated by stabilized cytosolic p27kip1. TM4SF5-
mediated EMT can lead to loss of contact inhibition and
enhanced migration/invasion, presumably depending on
cross-talks between TM4SF5 and integrins. An anti-
TM4SF5 agent appears to target the second extracellular
domain of TM4SF5, which is important for cross-talk with
integrins, leading to a blockade of TM4SF5-mediated
multilayer growth and migration/invasion. In addition,
TM4SF5 engages in cross-talk with integrin alpha5 to
induce and secrete VEGF, which in turn causes activation
of angiogenesis in endothelial cells. Therefore, TM4SF5
plays a central regulatory role in a wide variety of
physiological processes through cross-talk with integrins.
This review presents current knowledge from in vitro and
in vivo observations of the roles of TM4SF5-integrin
cooperation in hepatocellular carcinogenesis and discusses
important areas for future investigation.
en
dc.language.isoenen
dc.publisherFRONTIERS IN BIOSCIENCE INCen
dc.subject복합학en
dc.subjectCancer-
dc.subjectEpithelial-Mesenchymal Transition-
dc.subjectHepatocarcinoma-
dc.subjectIntegrin-
dc.subjectMicroenvironment-
dc.subjectTM4SF5-
dc.subjectReview-
dc.titleModulation of signaling between TM4SF5 and integrins in tumor microenvironmenten
dc.typeArticle-
dc.contributor.AlternativeAuthor이신애-
dc.contributor.AlternativeAuthor박기훈-
dc.contributor.AlternativeAuthor이정원-
dc.identifier.doi10.2741/3818-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2011-01/102/0000003910/1-
dc.description.srndSEQ:1-
dc.description.srndPERF_CD:SNU2011-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000003910-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A078142-
dc.description.srndDEPT_CD:375-
dc.description.srndCITE_RATE:4.048-
dc.description.srndFILENAME:60JWL_Frontier Bioscience.pdf-
dc.description.srndDEPT_NM:약학과-
dc.description.srndEMAIL:jwl@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.rimsid2422-
dc.identifier.srnd2011-01/102/0000003910/1-
dc.type.rimsART-
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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