Publications
Detailed Information
JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27Kip1 phosphorylation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyeonjung | - |
dc.contributor.author | Jung, Oisun | - |
dc.contributor.author | Kang, Minkyung | - |
dc.contributor.author | Lee, Mi-Sook | - |
dc.contributor.author | Jeong, Doyoung | - |
dc.contributor.author | Ryu, Jihye | - |
dc.contributor.author | Ko, Youra | - |
dc.contributor.author | Choi, Yoon-Ju | - |
dc.contributor.author | Lee, Jung Weon | - |
dc.creator | 이정원 | - |
dc.date.accessioned | 2013-04-16T07:54:23Z | - |
dc.date.available | 2013-04-16T07:54:23Z | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | CANCER LETTERS Vol.314 No.2, pp. 198-205 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://hdl.handle.net/10371/82069 | - |
dc.description.abstract | Transmembrane 4 L six family member 5 (TM4SF5) can regulate cell–cell adhesion and cellular
morphology via cytoplasmic p27Kip1-mediated changes in RhoA activity. However, how TM4SF5 causes cytosolic p27Kip1 stabilization remains unknown. In this study we found that TM4SF5-mediated Ser10 phosphorylation of p27Kip1 required for cytosolic localization was not always correlated with Akt activity. Inhibition or suppression of c-Jun Nterminal kinase (JNK) in TM4SF5-expressing cells decreased Ser10 phosphorylation of p27Kip1 and rescued expression levels and localization of adherence junction molecules to cell–cell contacts. These observations suggest involvement of JNKs in TM4SF5-mediated p27Kip1 Ser10 phosphorylation and localization during epithelial–mesenchymal transition. | en |
dc.language.iso | en | en |
dc.publisher | ELSEVIER | en |
dc.subject | 복합학 | en |
dc.subject | TM4SF5 | - |
dc.subject | Cytosolic p27Kip1 | - |
dc.subject | JNK | - |
dc.subject | Adherence junction | - |
dc.title | JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27Kip1 phosphorylation | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김현정 | - |
dc.contributor.AlternativeAuthor | 정외선 | - |
dc.contributor.AlternativeAuthor | 강민경 | - |
dc.contributor.AlternativeAuthor | 이미숙 | - |
dc.contributor.AlternativeAuthor | 정도영 | - |
dc.contributor.AlternativeAuthor | 류지혜 | - |
dc.contributor.AlternativeAuthor | 고유라 | - |
dc.contributor.AlternativeAuthor | 최윤주 | - |
dc.contributor.AlternativeAuthor | 이정원 | - |
dc.identifier.doi | 10.1016/j.canlet.2011.09.030 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000003910/2 | - |
dc.description.srnd | SEQ:2 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000003910 | - |
dc.description.srnd | ADJUST_YN:N | - |
dc.description.srnd | EMP_ID:A078142 | - |
dc.description.srnd | DEPT_CD:375 | - |
dc.description.srnd | CITE_RATE:4.238 | - |
dc.description.srnd | FILENAME:63HJK-CL.pdf | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:jwl@snu.ac.kr | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2012-01/102/0000003910/2 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.