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Effects of calcium phosphate endodontic sealers on the behavior of human periodontal ligament fibroblasts and MG63 osteoblast-like cells

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dc.contributor.authorShon, Won-Jun-
dc.contributor.authorBae, Kwang-Shik-
dc.contributor.authorBaek, Seung-Ho-
dc.contributor.authorKum, Kee-Yeon-
dc.contributor.authorHan, Ah-Reum-
dc.contributor.authorLee, Woo-Cheol-
dc.creator이우철-
dc.date.accessioned2013-05-01T06:31:31Z-
dc.date.available2013-05-01T06:31:31Z-
dc.date.issued2012-11-
dc.identifier.citationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS Vol.100B No.8, pp. 2141-2147-
dc.identifier.issn1552-4973-
dc.identifier.urihttp://hdl.handle.net/10371/82376-
dc.description.abstractIn regard to biological properties of endodontic
sealers, there are many characteristics that should be considered. The aim of this study was to examine the biological
effects of new calcium phosphate-based root canal sealers,
CAPSEAL I and CAPSEAL II (CPS), on human periodontal
fibroblast cells by examining the expression levels of inflammatory mediators and to compare the effects of CPS on the
viability and osteogenic potential of human osteoblast MG63
cells compared to those of other commercially available calcium phosphate sealers [Apatite Root Sealer type I (ARS I)
and Apatite Root Sealer III (ARS III); Sankin Kogyo, Tokyo, Japan] and a zinc oxide eugenol-based sealer (Pulp Canal
Sealer EWT [PCS EWT]; Kerr, Detroit, MI). The levels of IL-6
in the new CPS group (CAPSEAL I, II) were higher than those
in the control and all experimental groups at all time points
after 2 h. TGF-b1 and FGF-1 levels decreased at 72 h compared to the levels in the control, in cells treated with every
sealers except ARS I. The new CPS sealers showed low cytotoxicity. Reverse transcription polymerase chain reaction
showed that CAPSEAL I, II, and Apatite Root Sealer type III
induced expression of early stage markers of differentiation
(alkaline phosphatase and osteopontin) at 7 days. Also, new
CPS showed higher mineralized nodule formation at 28 days.
These results suggest that CAPSEAL I and II facilitate the
periapical dentoalveolar and alveolar healing by controlling
cellular mediators from PDL cells and osteoblast differentiation of precursor cells.
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dc.language.isoenen
dc.publisherWILEY-LISSen
dc.subject의약학en
dc.subjectCAPSEAL-
dc.subjectcalcium phosphate-based root canal
sealer
-
dc.subjecthuman periodontal fibroblast cells-
dc.subjectinflammatory mediator-
dc.subjectosteoblast differentiation-
dc.titleEffects of calcium phosphate endodontic sealers on the behavior of human periodontal ligament fibroblasts and MG63 osteoblast-like cellsen
dc.typeArticle-
dc.author.alternative손원준-
dc.author.alternative배광식-
dc.author.alternative백승호-
dc.author.alternative금기연-
dc.author.alternative한아름-
dc.author.alternative이우철-
dc.identifier.doi10.1002/jbm.b.32779-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000027976/9-
dc.description.srndSEQ:9-
dc.description.srndPERF_CD:SNU2012-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000027976-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A076085-
dc.description.srndDEPT_CD:861-
dc.description.srndCITE_RATE:2.147-
dc.description.srndFILENAME:JBMR-sealer.pdf-
dc.description.srndDEPT_NM:치의학과-
dc.description.srndEMAIL:jimin525@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2012-01/102/0000027976/9-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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