S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 02 No.3 (1961)
동물 및 사람태아 뇌조직 추출액의 Thromboplastin활성도에 관한 연구
Thromboplastic Activities of the Brain Extracts of Animals and Human Fetuses
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.2 No.3, pp. 45-53
- Thromboplastic activities of the acetone-treated brain
extracts of 20 rabbits. 20 dogs. 20 swines, 10bulls,
22 domestic fowls. 50 human fetuses. and 12, from
the new-borns. infants and adults were determined by
Quick's one stage method. The thromboplastin solutions
were made by adding physiological saline. 7cc in
animals. lOcc in humans, to 300mg of the powdered brain
extracts. The main objective of this study was to
investigate the relatioship between the tissue maturity
and thromboplastic activities.
1. In animals, the activity decreased in order of the
rabbit. bull. dog, swine and the domestic fowls, however,
no marked differences were observed between the
bull. dog and swine.
2. The activity in rabbit was higher than in human
and high uniformity was noted. The domestic fowls
showed the lowest activity and a marked individual
difference was also noted.
3. The activity in bull fell in order of the gray,
mixed and white matter although it was not so marked
as in humans. The least uniformity was observed
in the white matter.
4. In human fetuses. the activity tended to increase
with the lapse of months of gestation. The activity after
pregnancy 7th month in comparision to 4th month
showed a highly significant difference. It appears that
at least in human fetuses the thromboplastic activity
of the brain extracts bears a certain relationship with
the tissue maturity.
5. The activity upto pregnancy 9th month was 10·
wer than that of the adults. however. in 10th month
the activity, on the contrary, elevated than that of
the adults. This may be attributable to an increase of
the coagulantion factors in the maternal blood at the
latter half of gestation .
6. A notable fall of activity on 1 and 2 days after
the birth was observed.
7. There were no differences of activity on the basis
of sex and the twine fetuses.