동물 및 사람태아 뇌조직 추출액의 Thromboplastin활성도에 관한 연구

Abstract

Thromboplastic activities of the acetone-treated brain extracts of 20 rabbits. 20 dogs. 20 swines, 10bulls, 22 domestic fowls. 50 human fetuses. and 12, from the new-borns. infants and adults were determined by Quick's one stage method. The thromboplastin solutions were made by adding physiological saline. 7cc in animals. lOcc in humans, to 300mg of the powdered brain extracts. The main objective of this study was to investigate the relatioship between the tissue maturity and thromboplastic activities. 1. In animals, the activity decreased in order of the rabbit. bull. dog, swine and the domestic fowls, however, no marked differences were observed between the bull. dog and swine. 2. The activity in rabbit was higher than in human and high uniformity was noted. The domestic fowls showed the lowest activity and a marked individual difference was also noted. 3. The activity in bull fell in order of the gray, mixed and white matter although it was not so marked as in humans. The least uniformity was observed in the white matter. 4. In human fetuses. the activity tended to increase with the lapse of months of gestation. The activity after pregnancy 7th month in comparision to 4th month showed a highly significant difference. It appears that at least in human fetuses the thromboplastic activity of the brain extracts bears a certain relationship with the tissue maturity. 5. The activity upto pregnancy 9th month was 10· wer than that of the adults. however. in 10th month the activity, on the contrary, elevated than that of the adults. This may be attributable to an increase of the coagulantion factors in the maternal blood at the latter half of gestation . 6. A notable fall of activity on 1 and 2 days after the birth was observed. 7. There were no differences of activity on the basis of sex and the twine fetuses.