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Regulation of morphogenesis and neural differentiation of human mesenchymal stem cells using carbon nanotube sheets
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong Ah | - |
dc.contributor.author | Jang, Eui Yun | - |
dc.contributor.author | Kang, Tae June | - |
dc.contributor.author | Yoon, Sungjun | - |
dc.contributor.author | Ovalle-Robles, Raquel | - |
dc.contributor.author | Rhee, Won Jong | - |
dc.contributor.author | Kim, Taewoo | - |
dc.contributor.author | Baughman, Ray H. | - |
dc.contributor.author | Kim, Yong Hyup | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.creator | 박태현 | - |
dc.date.accessioned | 2013-07-31T00:16:10Z | - |
dc.date.available | 2013-07-31T00:16:10Z | - |
dc.date.created | 2018-07-09 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.citation | INTEGRATIVE BIOLOGY, Vol.4 No.6, pp.587-594 | - |
dc.identifier.issn | 1757-9694 | - |
dc.identifier.uri | https://hdl.handle.net/10371/83133 | - |
dc.description.abstract | In order to successfully utilize stem cells for therapeutic applications in regenerative medicine, efficient differentiation into a specific cell lineage and guidance of axons in a desired direction is crucial. Here, we used aligned multi-walled carbon nanotube (MWCNT) sheets to differentiate human mesenchymal stem cells (hMSCs) into neural cells. Human MSCs present a preferential adhesion to aligned CNT sheets with longitudinal stretch parallel to the CNT orientation direction. Cell elongation was 2-fold higher than the control and most of the cells were aligned on CNT sheets within 51 from the CNT orientation direction. Furthermore, a significant, synergistic enhancement of neural differentiation was observed in hMSCs cultured on the CNT sheets. Axon outgrowth was also controlled using nanoscale patterning of CNTs. This CNT sheet provides a new cellular scaffold platform that can regulate morphogenesis and differentiation of stem cells, which could open up a new approach for tissue and stem cell regeneration. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Regulation of morphogenesis and neural differentiation of human mesenchymal stem cells using carbon nanotube sheets | - |
dc.type | Article | - |
dc.author.alternative | 김정아 | - |
dc.author.alternative | 장의연 | - |
dc.author.alternative | 강태준 | - |
dc.author.alternative | 윤성준 | - |
dc.author.alternative | 이원종 | - |
dc.author.alternative | 김태우 | - |
dc.author.alternative | 김용협 | - |
dc.author.alternative | 박태현 | - |
dc.identifier.doi | 10.1039/c2ib20017a | - |
dc.citation.journaltitle | INTEGRATIVE BIOLOGY | - |
dc.identifier.wosid | 000304487300001 | - |
dc.identifier.scopusid | 2-s2.0-84874448393 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000002410/9 | - |
dc.description.srnd | SEQ:9 | - |
dc.description.srnd | PERF_CD:SNU2012-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000002410 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A002014 | - |
dc.description.srnd | DEPT_CD:458 | - |
dc.description.srnd | CITE_RATE:4.509 | - |
dc.description.srnd | FILENAME:Regulation of morphogenesis and neural differentiation of human.pdf | - |
dc.description.srnd | DEPT_NM:화학생물공학부 | - |
dc.description.srnd | EMAIL:thpark@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:N | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 594 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 587 | - |
dc.citation.volume | 4 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Yong Hyup | - |
dc.contributor.affiliatedAuthor | Park, Tai Hyun | - |
dc.identifier.srnd | 2012-01/102/0000002410/9 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ELECTROSPUN NANOFIBERS | - |
dc.subject.keywordPlus | AXONAL GROWTH | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordPlus | ATTACHMENT | - |
dc.subject.keywordPlus | MYOGENESIS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | GUIDANCE | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | FIBERS | - |
dc.subject.keywordPlus | FILMS | - |
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