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Characterization of a T7-Like Lytic Bacteriophage (SG-JL2) of Salmonella enterica Serovar Gallinarum Biovar Gallinarum

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dc.contributor.authorKwon, Hyuk-Joon-
dc.contributor.authorCho, Sun-Hee-
dc.contributor.authorKim, Tae-Eun-
dc.contributor.authorWon, Yong-Jin-
dc.contributor.authorJeong, Jihye-
dc.contributor.authorPark, Se Chang-
dc.contributor.authorKim, Jae-Hong-
dc.contributor.authorYoo, Han Sang-
dc.contributor.authorPark, Yong Ho-
dc.contributor.authorKim, Sun-Joong-
dc.date.accessioned2009-09-01-
dc.date.available2009-09-01-
dc.date.issued2008-
dc.identifier.citationAppl. Environ. Microbiol. 74:6970-6979en
dc.identifier.issn0099-2240-
dc.identifier.urihttps://hdl.handle.net/10371/8322-
dc.description.abstractSG-JL2 is a newly discovered lytic bacteriophage infecting Salmonella enterica serovar Gallinarum
biovar Gallinarum but is nonlytic to a rough vaccine strain of serovar Gallinarum biovar Gallinarum
(SG-9R), S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Gallinarum
biovar Pullorum. The SG-JL2 genome is 38,815 bp in length (GC content, 50.9%; 230-bp-long
direct terminal repeats), and 55 putative genes may be transcribed from the same strand. Functions were
assigned to 30 genes based on high amino acid similarity to known proteins. Most of the expected proteins
except tail fiber (31.9%) and the overall organization of the genomes were similar to those of yersiniophage
YeO3-12. SG-JL2 could be classified as a new T7-like virus and represents the first serovar Gallinarum
biovar Gallinarum phage genome to be sequenced. On the basis of intraspecific ratios of nonsynonymous
to synonymous nucleotide changes (Pi[a]/Pi[s]), gene 2 encoding the host RNA polymerase inhibitor
displayed Darwinian positive selection. Pretreatment of chickens with SG-JL2 before intratracheal
challenge with wild-type serovar Gallinarum biovar Gallinarum protected most birds from fowl typhoid.
Therefore, SG-JL2 may be useful for the differentiation of serovar Gallinarum biovar Gallinarum from
other Salmonella serotypes, prophylactic application in fowl typhoid control, and understanding of the
vertical evolution of T7-like viruses.
en
dc.description.sponsorshipThis study was partially supported by Korea Research Foundation
grants (KRF-2006-005-J02901 and KRF-2006-005-J02903).
en
dc.language.isoen-
dc.publisherAmerican Society for Microbiologyen
dc.titleCharacterization of a T7-Like Lytic Bacteriophage (SG-JL2) of Salmonella enterica Serovar Gallinarum Biovar Gallinarumen
dc.typeArticleen
dc.contributor.AlternativeAuthor권혁준-
dc.contributor.AlternativeAuthor조선희-
dc.contributor.AlternativeAuthor김태은-
dc.contributor.AlternativeAuthor원영진-
dc.contributor.AlternativeAuthor정지혜-
dc.contributor.AlternativeAuthor박세창-
dc.contributor.AlternativeAuthor김재홍-
dc.contributor.AlternativeAuthor유한상-
dc.contributor.AlternativeAuthor박용호-
dc.contributor.AlternativeAuthor김선중-
dc.identifier.doi10.1128/AEM.01088-08-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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