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Droplet-based microfluidic system to form and separate multicellular spheroids using magnetic nanoparticles

DC Field Value Language
dc.contributor.authorYoon, Sungjun-
dc.contributor.authorKim, Jeong Ah-
dc.contributor.authorLee, Seung Hwan-
dc.contributor.authorKim, Minsoo-
dc.contributor.authorPark, Tai Hyun-
dc.creator박태현-
dc.date.accessioned2013-08-14T00:50:45Z-
dc.date.available2013-08-14T00:50:45Z-
dc.date.created2018-07-09-
dc.date.created2018-07-09-
dc.date.issued2013-01-
dc.identifier.citationLAB ON A CHIP, Vol.13 No.8, pp.1522-1528-
dc.identifier.issn1473-0197-
dc.identifier.urihttps://hdl.handle.net/10371/83295-
dc.description.abstractThe importance of creating a three-dimensional (3-D) multicellular spheroid has recently been gaining attention due to the limitations of monolayer cell culture to precisely mimic in vivo structure and cellular interactions. Due to this emerging interest, researchers have utilized new tools, such as microfluidic devices, that allow high-throughput and precise size control to produce multicellular spheroids. We have developed a droplet-based microfluidic system that can encapsulate both cells and magnetic nanoparticles within alginate beads to mimic the function of a multicellular tumor spheroid. Cells were entrapped within the alginate beads along with magnetic nanoparticles, and the beads of a relatively uniform size (diameters of 85% of the beads were 170-190 mu m) were formed in the oil phase. These beads were passed through parallel streamlines of oil and culture medium, where the beads were magnetically transferred into the medium phase from the oil phase using an external magnetic force. This microfluidic chip eliminates additional steps for collecting the spheroids from the oil phase and transferring them to culture medium. Ultimately, the overall spheroid formation process can be achieved on a single microchip.-
dc.language영어-
dc.language.isoenen
dc.publisherROYAL SOC CHEMISTRY-
dc.titleDroplet-based microfluidic system to form and separate multicellular spheroids using magnetic nanoparticles-
dc.typeArticle-
dc.author.alternative윤성준-
dc.author.alternative김정아-
dc.author.alternative이승환-
dc.author.alternative김민수-
dc.author.alternative박태현-
dc.identifier.doi10.1039/c3lc41322e-
dc.citation.journaltitleLAB ON A CHIP-
dc.identifier.wosid000316275200012-
dc.identifier.scopusid2-s2.0-84876743164-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000002410/8-
dc.description.srndSEQ:8-
dc.description.srndPERF_CD:SNU2013-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000002410-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A002014-
dc.description.srndDEPT_CD:458-
dc.description.srndCITE_RATE:5.67-
dc.description.srndFILENAME:droplet-based microfluidic system to form and separate.pdf-
dc.description.srndDEPT_NM:화학생물공학부-
dc.description.srndEMAIL:thpark@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.citation.endpage1528-
dc.citation.number8-
dc.citation.startpage1522-
dc.citation.volume13-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorPark, Tai Hyun-
dc.identifier.srnd2013-01/102/0000002410/8-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusCELL-CULTURE-
dc.subject.keywordPlusHEPATOCYTE SPHEROIDS-
dc.subject.keywordPlusTUMOR SPHEROIDS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusMODEL-
dc.subject.keywordPlusGROWTH-
dc.subject.keywordPlusDIFFERENTIATION-
dc.subject.keywordPlusFIBROBLASTS-
dc.subject.keywordPlusTISSUE-
dc.subject.keywordPlusLIVER-
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