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Receptor-mediated gene delivery using chitosan derivatives in vitro and in vivo

Cited 2 time in Web of Science Cited 2 time in Scopus
Authors

Kim, T.-H.; Jiang, H.-L.; Nah, J.-W.; Cho, Myung-Haing; Akaike, T.; Cho, N.-S.

Issue Date
2007
Publisher
Wiley-Blackwell
Citation
Macromolecular Symposia, Vol.249-250, pp.137-144
Keywords
ChitosanLigand modificationNon-viral vectorReceptor-mediated gene deliveryTransfection efficiency
Abstract
The development of an efficient targeted gene delivery system into cells is an important strategy for the advancement of gene therapy. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relative low transfection efficiency. And it also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been investigated as a non-viral vector because it has several advantages such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this review, we focused on the specific ligand modification of chitosan for enhancement of cell specificity and transfection efficiency via receptor-mediated endocytosis in vitro and in vivo. Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA.
ISSN
1022-1360
Language
English
URI
https://hdl.handle.net/10371/8340
DOI
https://doi.org/10.1002/masy.200750323
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