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Bone formation around zirconia implants combined with rhBMP-2 gel in the canine mandible
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Byung-Chul | - |
dc.contributor.author | Yeo, In-Sung | - |
dc.contributor.author | Kim, Dae-Joon | - |
dc.contributor.author | Lee, Jai-Bong | - |
dc.contributor.author | Kim, Sung-Hun | - |
dc.contributor.author | Han, Jung-Suk | - |
dc.creator | 여인성 | - |
dc.date.accessioned | 2013-12-16T05:01:42Z | - |
dc.date.available | 2013-12-16T05:01:42Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | Clinical Oral Implants Research Vol.24 No.12, pp. 1332-1338 | - |
dc.identifier.issn | 0905-7161 (print) | - |
dc.identifier.issn | 1600-0501 (online) | - |
dc.identifier.uri | https://hdl.handle.net/10371/84899 | - |
dc.description.abstract | Objective : The aim of this study was to estimate the effects of zirconia implants and recombinant human bone morphogenetic protein-2 (rhBMP-2) gel on the acceleration of local bone formation and osseointegration in the canine mandible.
Materials and Methods : Four groups of 48 implants with identical geometry were installed in the mandibles of beagle dogs: alumina-blasted zirconia implants applied with rhBMP-2, alumina-blasted zirconia implants applied with demineralized bone matrix (DBM), alumina-blasted zirconia implants, and resorbable blast media-treated titanium (Ti) implants. For the first two groups, zirconia implants were inserted after the surgical sites were filled with rhBMP-2 or DBM gel. For the other two groups, zirconia or Ti implants were installed with no adjunctive treatment. Fluorescent bone markers were administered to monitor bone remodeling at weeks 2, 4, and 5 postimplantation. After healing periods of 3weeks and 6weeks, the animals were sacrificed, and fluorescent microscopy, histology, and histomorphometric analyses were performed. Results : Fluorescent microscopy showed that bone formation around the zirconia implants installed with rhBMP-2 gel was the most prominent at 2weeks postimplantation, while the Ti implants acquired bone apposition mainly at week 5. No significant differences were found in bone area among the groups (P>0.05). The zirconia implants showed similar bone-to-implant contact to the Ti implants. There were no significant differences in bone-to-implant contact between the zirconia implants with rhBMP-2 gel and those with DBM (P>0.05). Conclusions : The zirconia implants with alumina-blasted surfaces may achieve osseointegration in much the same manner as the well-established Ti implants. The area influenced by rhBMP-2 gel, including the alveolar crest, may cause active remodeling and early bone formation. | en |
dc.description.sponsorship | This research
was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0024170 & R01-2007- 000-10977-0). | - |
dc.language.iso | en | en |
dc.publisher | John Wiley & Sons A/S | en |
dc.subject | 복합학 | en |
dc.subject | alumina-toughened zirconia | - |
dc.subject | bone morphogenetic protein-2 | - |
dc.subject | bone response | - |
dc.subject | canine model | - |
dc.subject | zirconia implant | - |
dc.title | Bone formation around zirconia implants combined with rhBMP-2 gel in the canine mandible | en |
dc.type | Article | - |
dc.author.alternative | 이병철 | - |
dc.author.alternative | 여인성 | - |
dc.author.alternative | 김대준 | - |
dc.author.alternative | 이재봉 | - |
dc.author.alternative | 김성헌 | - |
dc.author.alternative | 한정석 | - |
dc.identifier.doi | 10.1111/clr.12004 | - |
dc.citation.journaltitle | Clinical Oral Implants Research | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2013-01/102/2008003883/13 | - |
dc.description.srnd | SEQ:13 | - |
dc.description.srnd | PERF_CD:SNU2013-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:2008003883 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A078517 | - |
dc.description.srnd | DEPT_CD:861 | - |
dc.description.srnd | CITE_RATE:3.433 | - |
dc.description.srnd | FILENAME:clin oral implants res 201312 24(12) 1332-8.pdf | - |
dc.description.srnd | DEPT_NM:치의학과 | - |
dc.description.srnd | EMAIL:pros53@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2013-01/102/2008003883/13 | - |
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