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Strain-specific differences in cell proliferation and differentiation in the dentate gyrus of C57BL/6N and C3H/HeN mice fed a high fat diet
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Kim, Il Yong | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Yoo, Ki-Yeon | - |
dc.contributor.author | Kim, Yo Na | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.contributor.author | Lee, In Se | - |
dc.contributor.author | Yoon, Yeo Sung | - |
dc.contributor.author | Sung, Je Kyeong | - |
dc.date.accessioned | 2009-09-03T22:29:47Z | - |
dc.date.available | 2009-09-03T22:29:47Z | - |
dc.date.issued | 2008-08-18 | - |
dc.identifier.citation | Brain Res. 1241, 1-6 | en |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8596 | - |
dc.description.abstract | The authors investigated strain-specific cell proliferation and differentiation differences in the dentate gyri of C57BL/6N (susceptible strain to obesity) and C3H/HeN (resistant strain to obesity) mice. In addition, the influences of a high fat diet (HD) on neuronal differentiation in C57BL/6N and C3H/HeN mice fed a low-fat diet (LD) or HD for 4 or 12 weeks were investigated. Body weight and body weight gains were significantly higher in HD-fed C57BL/6N and C3H/HeN mice than in LD-fed C57BL/6N and C3H/HeN mice. In particular, body weight gains were significantly higher in C57BL/6N mice than in C3H/HeN mice. In both of HD- and LD-fed C57BL/6N and C3H/HeN mice for 4 weeks, some Ki67 and many DCX immunoreactive cells were detected in the subgranular zone of the dentate gyrus. In HD-fed C57BL/6N and C3H/HeN mice, the number of Ki67 immunoreactive cells and DCX immunoreactivities in the dentate gyri were significantly lower than in LD-fed C57BL/6N and C3H/HeN mice. However, the number of Ki67 immunoreactive cells and DCX immunoreactivities in HD-fed C57BL/6N mice were significantly lower than in HD-fed C3H/HeN mice. These results suggest that C57BL/6N mice are more vulnerable to HD induced obesity than C3H/HeN mice. In addition, the feeding of HD was found to exacerbate reduced cell proliferation and differentiation in the dentate gyri of C57BL/6N mice as compared with that in C3H/HeN mice. | en |
dc.description.sponsorship | This work was supported by the Grants for MRC from Korean Ministry of Health and Welfare to Seong JK. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | High fat diet | en |
dc.subject | C57BL/6N | en |
dc.subject | C3H/HeN | en |
dc.subject | Doublecortin | en |
dc.subject | Ki-67 | en |
dc.subject | Dentate gyrus | en |
dc.subject | Obesity | en |
dc.title | Strain-specific differences in cell proliferation and differentiation in the dentate gyrus of C57BL/6N and C3H/HeN mice fed a high fat diet | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 황인구 | - |
dc.contributor.AlternativeAuthor | 김일용 | - |
dc.contributor.AlternativeAuthor | 김대원 | - |
dc.contributor.AlternativeAuthor | 유기연 | - |
dc.contributor.AlternativeAuthor | 김요나 | - |
dc.contributor.AlternativeAuthor | 이순신 | - |
dc.contributor.AlternativeAuthor | 원무호 | - |
dc.contributor.AlternativeAuthor | 이인세 | - |
dc.contributor.AlternativeAuthor | 윤여성 | - |
dc.contributor.AlternativeAuthor | 성제경 | - |
dc.identifier.doi | 10.1016/j.brainres.2008.08.024 | - |
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