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Strain-specific differences in cell proliferation and differentiation in the dentate gyrus of C57BL/6N and C3H/HeN mice fed a high fat diet

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dc.contributor.authorHwang, In Koo-
dc.contributor.authorKim, Il Yong-
dc.contributor.authorKim, Dae Won-
dc.contributor.authorYoo, Ki-Yeon-
dc.contributor.authorKim, Yo Na-
dc.contributor.authorYi, Sun Shin-
dc.contributor.authorWon, Moo-Ho-
dc.contributor.authorLee, In Se-
dc.contributor.authorYoon, Yeo Sung-
dc.contributor.authorSung, Je Kyeong-
dc.date.accessioned2009-09-03T22:29:47Z-
dc.date.available2009-09-03T22:29:47Z-
dc.date.issued2008-08-18-
dc.identifier.citationBrain Res. 1241, 1-6en
dc.identifier.issn0006-8993-
dc.identifier.urihttps://hdl.handle.net/10371/8596-
dc.description.abstractThe authors investigated strain-specific cell proliferation and differentiation differences in the dentate gyri of C57BL/6N (susceptible strain to obesity) and C3H/HeN (resistant strain to obesity) mice. In addition, the influences of a high fat diet (HD) on neuronal differentiation in C57BL/6N and C3H/HeN mice fed a low-fat diet (LD) or HD for 4 or 12 weeks were investigated. Body weight and body weight gains were significantly higher in HD-fed C57BL/6N and C3H/HeN mice than in LD-fed C57BL/6N and C3H/HeN mice. In particular, body weight gains were significantly higher in C57BL/6N mice than in C3H/HeN mice. In both of HD- and LD-fed C57BL/6N and C3H/HeN mice for 4 weeks, some Ki67 and many DCX immunoreactive cells were detected in the subgranular zone of the dentate gyrus. In HD-fed C57BL/6N and C3H/HeN mice, the number of Ki67 immunoreactive cells and DCX immunoreactivities in the dentate gyri were significantly lower than in LD-fed C57BL/6N and C3H/HeN mice. However, the number of Ki67 immunoreactive cells and DCX immunoreactivities in HD-fed C57BL/6N mice were significantly lower than in HD-fed C3H/HeN mice. These results suggest that C57BL/6N mice are more vulnerable to HD induced obesity than C3H/HeN mice. In addition, the feeding of HD was found to exacerbate reduced cell proliferation and differentiation in the dentate gyri of C57BL/6N mice as compared with that in C3H/HeN mice.en
dc.description.sponsorshipThis work was supported by the Grants for MRC from Korean Ministry of Health and Welfare to Seong JK.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectHigh fat dieten
dc.subjectC57BL/6Nen
dc.subjectC3H/HeNen
dc.subjectDoublecortinen
dc.subjectKi-67en
dc.subjectDentate gyrusen
dc.subjectObesityen
dc.titleStrain-specific differences in cell proliferation and differentiation in the dentate gyrus of C57BL/6N and C3H/HeN mice fed a high fat dieten
dc.typeArticleen
dc.contributor.AlternativeAuthor황인구-
dc.contributor.AlternativeAuthor김일용-
dc.contributor.AlternativeAuthor김대원-
dc.contributor.AlternativeAuthor유기연-
dc.contributor.AlternativeAuthor김요나-
dc.contributor.AlternativeAuthor이순신-
dc.contributor.AlternativeAuthor원무호-
dc.contributor.AlternativeAuthor이인세-
dc.contributor.AlternativeAuthor윤여성-
dc.contributor.AlternativeAuthor성제경-
dc.identifier.doi10.1016/j.brainres.2008.08.024-
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