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Persistent Pain Is Dependent on Spinal Mitochondrial Antioxidant Levels
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Schwartz, Erica S. | - |
dc.contributor.author | Kim, Hee Young | - |
dc.contributor.author | Wang, Jigong | - |
dc.contributor.author | Lee, Inhyung | - |
dc.contributor.author | Klann, Eric | - |
dc.contributor.author | Chung, Jin Mo | - |
dc.contributor.author | Chung, Kyungsoon | - |
dc.date.accessioned | 2009-09-03T22:50:49Z | - |
dc.date.available | 2009-09-03T22:50:49Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | J Neurosci 29:159-168 | en |
dc.identifier.issn | 0270-6474 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8613 | - |
dc.description.abstract | Reactive oxygen species (ROS) scavengers have been shown to relieve persistent pain; however, the mechanism is not clearly understood.
Superoxide produced from mitochondrial oxidative phosphorylation is considered the major source of ROS in neurons during excitation where mitochondrial superoxide levels are normally controlled by superoxide dismutase (SOD-2). The present study hypothesizes that capsaicin-induced secondary hyperalgesia is a consequence of superoxide build-up in spinal dorsal horn neurons and SOD-2 is a major determinant. To test this hypothesis, the spinal levels of SOD-2 activity, inactivated SOD-2 proteins, and mitochondrial superoxide were measured and correlated to the levels of capsaicin-induced secondary hyperalgesia in mice with and without SOD-2 manipulations. The data suggest that superoxide accumulation is a culprit in the abnormal sensory processing in the spinal cord in capsaicin-induced secondary hyperalgesia. Our studies also support the notion that SOD-2 nitration is a critical mechanism that maintains elevated superoxide levels in the spinal cord after capsaicin treatment. Finally, our findings suggest a therapeutic potential for the manipulation of spinal SOD-2 activity in pain conditions. | en |
dc.description.sponsorship | This work was supported by National Institutes of Health Grants R01 NS31680 and P01 NS11255. | en |
dc.language.iso | en | en |
dc.publisher | Society for Neuroscience | en |
dc.subject | oxidative stress | en |
dc.subject | persistent pain | en |
dc.subject | central sensitization | en |
dc.subject | SOD-2 | en |
dc.subject | superoxide | en |
dc.subject | mitochondria | en |
dc.title | Persistent Pain Is Dependent on Spinal Mitochondrial Antioxidant Levels | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김희영 | - |
dc.contributor.AlternativeAuthor | 이인형 | - |
dc.contributor.AlternativeAuthor | 정진모 | - |
dc.contributor.AlternativeAuthor | 정경선 | - |
dc.identifier.doi | 10.1523/JNEUROSCI.3792-08.2009 | - |
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