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Acute liver toxicity by carbon tetrachloride in HSP70 knock out mice

Cited 19 time in Web of Science Cited 26 time in Scopus
Authors
Song, Ji-Ye; Li, Lan; Ahn, Jae-Bum; Park, Jong-Gil; Jo, Ji-Sang; Park, Dae-Hun; Jang, Hyung-Kwan; Jang, Ja June; Lee, Min-Jae
Issue Date
2007-06-22
Publisher
Elsevier
Citation
Experimental and Toxicologic Pathology 2007;59:29-34
Keywords
Acute liver toxicityHSP70Knock outMiceCarbon tetrachloride (CCl4)
Abstract
The effects of carbon tetrachloride (CCl(4)) treatment on acute liver damage in knock out (heat shock proteins -- HSP70-/-) mice and wild-type (C57BL/6) mice were examined. Acute liver injury was induced by a single intraperitoneal injection of 0.3 ML/kg CCl(4) in olive oil. Mice were sacrificed at 12, 24, 48 and 72 h after treatment. To assess hepatotoxicity, alanine transaminase, neutrophil infiltration and degree of necrosis were measured. Western blot analysis was employed for heat shock proteins. The result revealed that HSP70-/- mice showed higher alanine transaminase levels and a more severe degree of neutrophilic infiltration and necrosis than those of wild-type mice. Furthermore, HSP70-/- mice recovered more slowly from CCl(4) treatment. In HSP70-/- mice, HSP47 was overexpressed. Therefore, HSP70-/- mice could be an adequate model of acute liver toxicity study.
ISSN
0940-2993
Language
English
URI
http://hdl.handle.net/10371/9011
DOI
https://doi.org/10.1016/j.etp.2007.02.005
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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