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Acute liver toxicity by carbon tetrachloride in HSP70 knock out mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Ji-Ye | - |
dc.contributor.author | Li, Lan | - |
dc.contributor.author | Ahn, Jae-Bum | - |
dc.contributor.author | Park, Jong-Gil | - |
dc.contributor.author | Jo, Ji-Sang | - |
dc.contributor.author | Park, Dae-Hun | - |
dc.contributor.author | Jang, Hyung-Kwan | - |
dc.contributor.author | Jang, Ja June | - |
dc.contributor.author | Lee, Min-Jae | - |
dc.date.accessioned | 2009-09-09T01:06:07Z | - |
dc.date.available | 2009-09-09T01:06:07Z | - |
dc.date.issued | 2007-06-22 | - |
dc.identifier.citation | Experimental and Toxicologic Pathology 2007;59:29-34 | en |
dc.identifier.issn | 0940-2993 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9011 | - |
dc.description.abstract | The effects of carbon tetrachloride (CCl(4)) treatment on acute liver damage in knock out (heat shock proteins -- HSP70-/-) mice and wild-type (C57BL/6) mice were examined. Acute liver injury was induced by a single intraperitoneal injection of 0.3 ML/kg CCl(4) in olive oil. Mice were sacrificed at 12, 24, 48 and 72 h after treatment. To assess hepatotoxicity, alanine transaminase, neutrophil infiltration and degree of necrosis were measured. Western blot analysis was employed for heat shock proteins. The result revealed that HSP70-/- mice showed higher alanine transaminase levels and a more severe degree of neutrophilic infiltration and necrosis than those of wild-type mice. Furthermore, HSP70-/- mice recovered more slowly from CCl(4) treatment. In HSP70-/- mice, HSP47 was overexpressed. Therefore, HSP70-/- mice could be an adequate model of acute liver toxicity study. | en |
dc.description.sponsorship | This research was supported by the Kangwon
National University. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Acute liver toxicity | en |
dc.subject | HSP70 | en |
dc.subject | Knock out | en |
dc.subject | Mice | en |
dc.subject | Carbon tetrachloride (CCl4) | en |
dc.title | Acute liver toxicity by carbon tetrachloride in HSP70 knock out mice | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 송지예 | - |
dc.contributor.AlternativeAuthor | 이란 | - |
dc.contributor.AlternativeAuthor | 안재범 | - |
dc.contributor.AlternativeAuthor | 박종길 | - |
dc.contributor.AlternativeAuthor | 조지상 | - |
dc.contributor.AlternativeAuthor | 박대훈 | - |
dc.contributor.AlternativeAuthor | 장형관 | - |
dc.contributor.AlternativeAuthor | 장자준 | - |
dc.contributor.AlternativeAuthor | 이민재 | - |
dc.identifier.doi | 10.1016/j.etp.2007.02.005 | - |
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