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Anti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages

Cited 2 time in Web of Science Cited 2 time in Scopus
Authors
Chang, Mi-Ra; Lee, Woong Hee; Rhee, Won Jong; Park, Tai Hyun; Kim, Eun Jeong
Issue Date
2013-09-01
Publisher
Springer US
Citation
Korean Journal of Chemical Engineering Vol.30 No.9, pp. 1784-1789
Keywords
복합학MacrophagesSilkworm HemolymphNitric Oxide (NO)Inducible Nitric Oxide Synthase (iNOS)Pro-inflammatory Cytokines
Abstract
Macrophages participate in several inflammatory pathologies such as sepsis and arthritis. We investigated the effect of silkworm hemolymph (SH) on the LPS-induced pro-inflammatory macrophages. SH inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and murine peritoneal macrophages. The decreased NO was reflected as a decreased amount of inducible nitric oxide synthase (iNOS) mRNA and protein. It was also found that SR inhibited pro-inflammatory cytokines, IL-1 beta, IL-6, and TNF-alpha production. To elucidate the mechanism by which SR inhibits NO production and iNOS expression, we investigated that SR suppressed I kappa B phosphorylation, which leads to the activation of NF-kappa B followed by degradation of I kappa B. This observation suggests that SH is a potential therapeutic modulator for inflammation-associated disorders.
ISSN
0256-1115 (print)
1975-7220 (online)
Language
English
URI
https://hdl.handle.net/10371/90918
DOI
https://doi.org/10.1007/s11814-013-0108-6
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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