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Anti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages
Cited 2 time in
Web of Science
Cited 2 time in Scopus
- Authors
- Issue Date
- 2013-09
- Publisher
- KOREAN INSTITUTE CHEMICAL ENGINEERS
- Citation
- KOREAN JOURNAL OF CHEMICAL ENGINEERING, Vol.30 No.9, pp.1784-1789
- Abstract
- Macrophages participate in several inflammatory pathologies such as sepsis and arthritis. We investigated the effect of silkworm hemolymph (SH) on the LPS-induced pro-inflammatory macrophages. SH inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and murine peritoneal macrophages. The decreased NO was reflected as a decreased amount of inducible nitric oxide synthase (iNOS) mRNA and protein. It was also found that SR inhibited pro-inflammatory cytokines, IL-1 beta, IL-6, and TNF-alpha production. To elucidate the mechanism by which SR inhibits NO production and iNOS expression, we investigated that SR suppressed I kappa B phosphorylation, which leads to the activation of NF-kappa B followed by degradation of I kappa B. This observation suggests that SH is a potential therapeutic modulator for inflammation-associated disorders.
- ISSN
- 0256-1115
- Language
- English
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