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Anti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages

DC Field Value Language
dc.contributor.authorChang, Mi-Ra-
dc.contributor.authorLee, Woong Hee-
dc.contributor.authorRhee, Won Jong-
dc.contributor.authorPark, Tai Hyun-
dc.contributor.authorKim, Eun Jeong-
dc.creator박태현-
dc.date.accessioned2014-02-14T00:37:38Z-
dc.date.available2014-02-14T00:37:38Z-
dc.date.created2018-07-09-
dc.date.issued2013-09-
dc.identifier.citationKOREAN JOURNAL OF CHEMICAL ENGINEERING, Vol.30 No.9, pp.1784-1789-
dc.identifier.issn0256-1115-
dc.identifier.urihttps://hdl.handle.net/10371/90918-
dc.description.abstractMacrophages participate in several inflammatory pathologies such as sepsis and arthritis. We investigated the effect of silkworm hemolymph (SH) on the LPS-induced pro-inflammatory macrophages. SH inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and murine peritoneal macrophages. The decreased NO was reflected as a decreased amount of inducible nitric oxide synthase (iNOS) mRNA and protein. It was also found that SR inhibited pro-inflammatory cytokines, IL-1 beta, IL-6, and TNF-alpha production. To elucidate the mechanism by which SR inhibits NO production and iNOS expression, we investigated that SR suppressed I kappa B phosphorylation, which leads to the activation of NF-kappa B followed by degradation of I kappa B. This observation suggests that SH is a potential therapeutic modulator for inflammation-associated disorders.-
dc.language영어-
dc.language.isoenen
dc.publisherKOREAN INSTITUTE CHEMICAL ENGINEERS-
dc.titleAnti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages-
dc.typeArticle-
dc.author.alternative장미라-
dc.author.alternative이웅희-
dc.author.alternative이원종-
dc.author.alternative박태현-
dc.author.alternative김은정-
dc.identifier.doi10.1007/s11814-013-0108-6-
dc.citation.journaltitleKOREAN JOURNAL OF CHEMICAL ENGINEERING-
dc.identifier.wosid000323916500017-
dc.identifier.scopusid2-s2.0-84883829176-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000002410/14-
dc.description.srndSEQ:14-
dc.description.srndPERF_CD:SNU2013-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000002410-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A002014-
dc.description.srndDEPT_CD:458-
dc.description.srndCITE_RATE:1.059-
dc.description.srndFILENAME:14. (2013.09) anti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages.pdf-
dc.description.srndDEPT_NM:화학생물공학부-
dc.description.srndEMAIL:thpark@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.citation.endpage1789-
dc.citation.number9-
dc.citation.startpage1784-
dc.citation.volume30-
dc.identifier.kciidART001795633-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorPark, Tai Hyun-
dc.identifier.srnd2013-01/102/0000002410/14-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusNITRIC-OXIDE SYNTHASE-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusBOMBYX-MORI-
dc.subject.keywordPlusIMMUNE-RESPONSES-
dc.subject.keywordPlusCELL APOPTOSIS-
dc.subject.keywordPlusRECOMBINANT PROTEIN-
dc.subject.keywordPlusPARALYTIC PEPTIDE-
dc.subject.keywordPlusESCHERICHIA-COLI-
dc.subject.keywordPlusEPO PRODUCTION-
dc.subject.keywordPlusTNF-ALPHA-
dc.subject.keywordAuthorMacrophages-
dc.subject.keywordAuthorSilkworm Hemolymph-
dc.subject.keywordAuthorNitric Oxide (NO)-
dc.subject.keywordAuthorInducible Nitric Oxide Synthase (iNOS)-
dc.subject.keywordAuthorPro-inflammatory Cytokines-
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