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Anti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Mi-Ra | - |
dc.contributor.author | Lee, Woong Hee | - |
dc.contributor.author | Rhee, Won Jong | - |
dc.contributor.author | Park, Tai Hyun | - |
dc.contributor.author | Kim, Eun Jeong | - |
dc.creator | 박태현 | - |
dc.date.accessioned | 2014-02-14T00:37:38Z | - |
dc.date.available | 2014-02-14T00:37:38Z | - |
dc.date.created | 2018-07-09 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.citation | KOREAN JOURNAL OF CHEMICAL ENGINEERING, Vol.30 No.9, pp.1784-1789 | - |
dc.identifier.issn | 0256-1115 | - |
dc.identifier.uri | https://hdl.handle.net/10371/90918 | - |
dc.description.abstract | Macrophages participate in several inflammatory pathologies such as sepsis and arthritis. We investigated the effect of silkworm hemolymph (SH) on the LPS-induced pro-inflammatory macrophages. SH inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and murine peritoneal macrophages. The decreased NO was reflected as a decreased amount of inducible nitric oxide synthase (iNOS) mRNA and protein. It was also found that SR inhibited pro-inflammatory cytokines, IL-1 beta, IL-6, and TNF-alpha production. To elucidate the mechanism by which SR inhibits NO production and iNOS expression, we investigated that SR suppressed I kappa B phosphorylation, which leads to the activation of NF-kappa B followed by degradation of I kappa B. This observation suggests that SH is a potential therapeutic modulator for inflammation-associated disorders. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | KOREAN INSTITUTE CHEMICAL ENGINEERS | - |
dc.title | Anti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages | - |
dc.type | Article | - |
dc.author.alternative | 장미라 | - |
dc.author.alternative | 이웅희 | - |
dc.author.alternative | 이원종 | - |
dc.author.alternative | 박태현 | - |
dc.author.alternative | 김은정 | - |
dc.identifier.doi | 10.1007/s11814-013-0108-6 | - |
dc.citation.journaltitle | KOREAN JOURNAL OF CHEMICAL ENGINEERING | - |
dc.identifier.wosid | 000323916500017 | - |
dc.identifier.scopusid | 2-s2.0-84883829176 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000002410/14 | - |
dc.description.srnd | SEQ:14 | - |
dc.description.srnd | PERF_CD:SNU2013-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000002410 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A002014 | - |
dc.description.srnd | DEPT_CD:458 | - |
dc.description.srnd | CITE_RATE:1.059 | - |
dc.description.srnd | FILENAME:14. (2013.09) anti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages.pdf | - |
dc.description.srnd | DEPT_NM:화학생물공학부 | - |
dc.description.srnd | EMAIL:thpark@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 1789 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | 1784 | - |
dc.citation.volume | 30 | - |
dc.identifier.kciid | ART001795633 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Park, Tai Hyun | - |
dc.identifier.srnd | 2013-01/102/0000002410/14 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | BOMBYX-MORI | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | CELL APOPTOSIS | - |
dc.subject.keywordPlus | RECOMBINANT PROTEIN | - |
dc.subject.keywordPlus | PARALYTIC PEPTIDE | - |
dc.subject.keywordPlus | ESCHERICHIA-COLI | - |
dc.subject.keywordPlus | EPO PRODUCTION | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordAuthor | Macrophages | - |
dc.subject.keywordAuthor | Silkworm Hemolymph | - |
dc.subject.keywordAuthor | Nitric Oxide (NO) | - |
dc.subject.keywordAuthor | Inducible Nitric Oxide Synthase (iNOS) | - |
dc.subject.keywordAuthor | Pro-inflammatory Cytokines | - |
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