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Evaluation of the efficacy of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in a mini-pig spinal anterior interbody fusion model

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dc.contributor.authorHwang, C. J.-
dc.contributor.authorLee, J. H.-
dc.contributor.authorBaek, H-R.-
dc.contributor.authorChang, B-S.-
dc.contributor.authorLee, C-K.-
dc.creator이재협-
dc.date.accessioned2014-02-24T00:26:49Z-
dc.date.available2014-02-24T00:26:49Z-
dc.date.issued2013-02-
dc.identifier.citationBone & Joint Journal Vol.95-B No.2, pp. 217-223-
dc.identifier.issn2049-4394 (print)-
dc.identifier.issn2049-4408 (online)-
dc.identifier.urihttps://hdl.handle.net/10371/90965-
dc.description.abstractWe evaluated the efficacy of Escherichia coli-derived recombinant human bone morphogenetic protein-2 (E-BMP-2) in a mini-pig model of spinal anterior interbody fusion. A total of 14 male mini-pigs underwent three-level anterior lumbar interbody fusion using polyether etherketone (PEEK) cages containing porous hydroxyapatite (HA). Four groups of cages were prepared: 1) control (n = 10 segments); 2) 50 μg E-BMP-2 (n = 9); 3) 200 μg E-BMP-2 (n = 10); and 4) 800 μg E-BMP-2 (n = 9). At eight weeks after surgery the mini-pigs were killed and the specimens were evaluated by gross inspection and manual palpation, radiological evaluation including plain radiographs and micro-CT scans, and histological analysis. Rates of fusion within PEEK cages and overall union rates were calculated, and bone formation outside vertebrae was evaluated. One animal died post-operatively and was excluded, and one section was lost and also excluded, leaving 38 sites for assessment. This rate of fusion within cages was 30.0% (three of ten) in the control group, 44.4% (four of nine) in the 50 μg E-BMP-2 group, 60.0% (six of ten) in the 200 μg E-BMP-2 group, and 77.8% (seven of nine) in the 800 μg E-BMP-2 group. Fusion rate was significantly increased by the addition of E-BMP-2 and with increasing E-BMP-2 dose (p = 0.046). In a mini-pig spinal anterior interbody fusion model using porous HA as a carrier, the implantation of E-BMP-2-loaded PEEK cages improved the fusion rate compared with PEEK cages alone, an effect that was significantly increased with increasing E-BMP-2 dosage.-
dc.description.sponsorshipThis research was financially supported by a grant from Daewoong Pharmaceutical Corporation, Seoul, Korea.-
dc.language.isoenen
dc.publisherThe British Editorial
Society of Bone & Joint
Surgery
en
dc.subject복합학en
dc.titleEvaluation of the efficacy of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in a mini-pig spinal anterior interbody fusion modelen
dc.typeArticle-
dc.author.alternative황창주-
dc.author.alternative이재협-
dc.author.alternative백해리-
dc.author.alternative장봉순-
dc.author.alternative이춘기-
dc.identifier.doi10.1302/0301-620X.95B2.29466-
dc.citation.journaltitleBone & Joint Journal-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000007273/1-
dc.description.srndSEQ:1-
dc.description.srndPERF_CD:SNU2013-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000007273-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A077517-
dc.description.srndDEPT_CD:801-
dc.description.srndCITE_RATE:2.689-
dc.description.srndFILENAME:첨부된 내역이 없습니다.-
dc.description.srndDEPT_NM:의학과-
dc.description.srndEMAIL:spinelee@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2013-01/102/0000007273/1-
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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