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Genetic and environmental influences on sodium intake determined by using half-day urine samples: the Healthy Twin Study

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dc.contributor.authorKho, Minjung-
dc.contributor.authorLee, Jung Eun-
dc.contributor.authorSong, Yun-Mi-
dc.contributor.authorLee, Kayoung-
dc.contributor.authorKim, Kyunga-
dc.contributor.authorYang, Sarah-
dc.contributor.authorJoung, Hyojee-
dc.contributor.authorSung, Joohon-
dc.creator성주헌-
dc.date.accessioned2014-03-25T02:32:13Z-
dc.date.available2014-03-25T02:32:13Z-
dc.date.issued2013-12-
dc.identifier.citationAmerican Journal of Clinical Nutrition Vol.98 No.6, pp. 1410-1416-
dc.identifier.issn0002-9165 (print)-
dc.identifier.issn1938-3207 (online)-
dc.identifier.urihttps://hdl.handle.net/10371/91215-
dc.identifier.urihttp://ajcn.nutrition.org/content/98/6/1410/suppl/DCSupplemental-
dc.identifier.urihttp://ajcn.nutrition.org/content/98/6/1410.full.pdf+html-
dc.description.abstractBackground: Salt is essential in our diet, but excess intake is a well-established risk factor for hypertension. The presence and importance of genetic contributions to salt intake, however, are not well understood.Objective: The aim of this study was to examine whether a genetic predisposition and an environmental influence exist for sodium intake and salt habit.Design: In a twin-family cohort, half-day urine samples from 1204 individuals (133 pairs of monozygotic twins, 29 pairs of dizygotic twins, and 880 singletons) were collected to assess 24-h sodium intakes. Daily total sodium intake, sodium density per calorie (Na-D), and salt habit questions were analyzed with adjustment for other epidemiologic characteristics. We calculated heritability (h2) and intraclass correlations to examine the genetic and shared environmental contributions to total sodium intake traits.Results: The average sodium intake was 208.4 +/- 107.0 mmol/d. Men had a higher absolute sodium intake (242.6 +/- 117.4 mmol/d), but Na-D did not differ by sex. Moderate genetic influences existed (h2 = 0.31-0.34) for sodium intake and Na-D. We also found that sharing current residence rather than being a family member explained 22% of the variance in Na-D.Conclusion: Our findings suggest that both genetic predisposition and shared environment contribute to sodium intakes and salt habits alike.en
dc.language.isoenen
dc.publisherAmerican Society for Nutritionen
dc.subject복합학en
dc.titleGenetic and environmental influences on sodium intake determined by using half-day urine samples: the Healthy Twin Studyen
dc.typeArticle-
dc.author.alternative고민정-
dc.author.alternative이정은-
dc.author.alternative송윤미-
dc.author.alternative이가영-
dc.author.alternative김경아-
dc.author.alternative양사라-
dc.author.alternative정효지-
dc.author.alternative성주헌-
dc.citation.journaltitleAmerican Journal of Clinical Nutrition-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2013-01/102/0000040632/14-
dc.description.srndSEQ:14-
dc.description.srndPERF_CD:SNU2013-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:0000040632-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A077602-
dc.description.srndDEPT_CD:902-
dc.description.srndCITE_RATE:6.504-
dc.description.srndFILENAME:12.genetic and environmental influences on sodium intake determined by_pgm_twin_grn.pdf-
dc.description.srndDEPT_NM:보건학과-
dc.description.srndEMAIL:jsung@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2013-01/102/0000040632/14-
Appears in Collections:
Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Journal Papers (저널논문_보건학과)
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