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Pituitary adenoma with rich folliculo-stellate cells and mucin-producing epithelia arising in a 2-year-old girl

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dc.contributor.authorMin, Hye Sook-
dc.contributor.authorLee, Seung June-
dc.contributor.authorKim, Seung-Ki-
dc.contributor.authorPark, Sung-Hye-
dc.date.accessioned2009-09-10T05:45:18Z-
dc.date.available2009-09-10T05:45:18Z-
dc.date.issued2007-08-10-
dc.identifier.citationPathol Int 2007; 57: 600-5en
dc.identifier.issn1320-5463 (print)-
dc.identifier.issn1440-1827 (online)-
dc.identifier.urihttp://hdl.handle.net/10371/9121-
dc.description.abstractPituitary adenoma is a rare neoplasm in childhood, with prolactin and adrenocorticotropic hormone (ACTH)-secreting adenomas predominating in this age group. Herein is reported a case of an ACTH-producing macroadenoma with an unusual histology that occurred in a 2-year-old girl. Because of the patient's age and the macroadenoma's suprasellar location and large size (up to 4 cm in diameter), radical surgery was performed under the suspicion of craniopharyngioma or germ-cell tumor. Pathologically, it was a unique pituitary adenoma composed of monotonous ACTH-producing cells, smaller folliculo-stellate cells (FSC), and mucin-producing cells. The FSC, non-hormone-secreting pituitary cells of uncertain function, were confirmed by their S-100 protein, glial fibrillary acidic protein and cytokeratin expression immunoprofiles. The abrupt transition between the prominent gland-forming mucin-producing epithelia and the FSC component suggested that the mucin-producing epithelia might be derived from the FSC. This association might represent so-called 'retrodifferentiation' of adenoma cells to the FSC and the precursor cells of Rathke's pouch.en
dc.description.sponsorshipThis work was supported by grant no. 7-2005-1216 ‘Study of
Multicenter Trial for Standardization of therapeutic Guidelines
in Pediatric Brain Tumors’ from the Korean Ministry of Health
and Welfare.
en
dc.language.isoen-
dc.publisherWiley-Blackwellen
dc.publisherJapanese Society of Pathology-
dc.subjectfolliculo-stellate cellen
dc.subjectmucin-producing epitheliumen
dc.subjectpituitary adenomaen
dc.subjectRathke’s pouchen
dc.subjectretrodifferentiationen
dc.titlePituitary adenoma with rich folliculo-stellate cells and mucin-producing epithelia arising in a 2-year-old girlen
dc.typeArticleen
dc.contributor.AlternativeAuthor민혜숙-
dc.contributor.AlternativeAuthor이승준-
dc.contributor.AlternativeAuthor김승기-
dc.contributor.AlternativeAuthor박성혜-
dc.identifier.doi10.1111/j.1440-1827.2007.02145.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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