trans-1, 4, 5, 6 Tetrahydro-2-(3-hydroxystyryI)-1-methylpyrimidine(CP-14,445)의 Trichocephalus trichiurus에 대한 구충효과

Abstract

CP-14,445, one of pyrimidine derivative, has been expected to be a potent antiwhipworm agent for Trichocephalus trichiurus, and its activity in human infestation, its side effect , and safety through pre• liminary trial is the subject of the present study. In 70 case of Trichocephalus trichiurus infestation one single oral dose of 10mg/kg of CP•14.445 as a syrup formulation. produced following results. CP-14.445 showed negative conversion rate of 63% for T. trichiurus but its egg reduction rate at 22nd post-treatment day was 91.5% For the Ascariasis, no effect was observed with one single oral dose of 10mg/kg In all tested cases , one single oral dose of 10 mg/kg of CP-14,445 was well tolerated and there was no detectable objective and/or subjective side effect. Blood chemistry, blood film and urinalysis were taken in all patients and CP-14,445 was so safe as to revel that no difference was observed between pre- and post-treatment with one single oral dose of 10mg/kg of CP-14,445.