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Expression of epidermal CAMP changes in parallel with permeability barrier status

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dc.contributor.authorRodriguez-Martin, Marina-
dc.contributor.authorMartin-Ezquerra, Gemma-
dc.contributor.authorMan, Mao-Qiang-
dc.contributor.authorHupe, Melanie-
dc.contributor.authorYoum, Jong-Kyung-
dc.contributor.authorMackenzie, Donald S.-
dc.contributor.authorCho, Soyun-
dc.contributor.authorTrullas, Carles-
dc.contributor.authorHolleran, Walter M.-
dc.contributor.authorRadek, Katherine A.-
dc.contributor.authorElias, Peter M.-
dc.creator조소연-
dc.date.accessioned2014-09-02T00:08:15Z-
dc.date.available2014-09-02T00:08:15Z-
dc.date.issued2011-07-
dc.identifier.citationJournal of Investigative Dermatology, Vol.131 No.1, pp. 2263-2270-
dc.identifier.issn0022-202X-
dc.identifier.urihttps://hdl.handle.net/10371/92998-
dc.description.abstractTwo critical defensive functions of the outer epidermis, the permeability barrier and antimicrobial defense, share certain structural and biochemical features. Moreover, three antimicrobial peptides (AMPs), i.e., mouse β-defensin 3 (mBD3), mouse cathelicidin antimicrobial peptide (mCAMP), and the neuroendocrine peptide, catestatin (Cst), all localize to the outer epidermis, and both mBD3 and mCAMP are secreted from the epidermal lamellar bodies with other organelle contents that subserve the permeability barrier. These three AMPs are upregulated in response to acute permeability barrier disruption, whereas conversely, mCAMP−/− mice (unable to combat Gram-positive pathogens) also display abnormal barrier homeostasis. To determine further whether these two functions are co-regulated, we investigated changes in immunostaining for these three AMPs in skin samples in which the permeability barrier function in mice had been either compromised or enhanced. Compromised or enhanced barrier function correlated with reduced or enhanced immunohistochemical expression of mCAMP, respectively, but conversely with Cst expression, likely due to the role of this AMP as an endogenous inhibitor of cathelicidin expression. mBD3 expression correlated with experimental barrier perturbations, but poorly with developmental changes in barrier function. These studies show that changes in cathelicidin and Cst expression parallel changes in permeability barrier status, with a less clear relationship with mBD3 expression.-
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.subject복합학en
dc.titleExpression of epidermal CAMP changes in parallel with permeability barrier statusen
dc.typeArticle-
dc.contributor.AlternativeAuthor염종경-
dc.contributor.AlternativeAuthor조소연-
dc.identifier.doi10.1038/jid.2011.210-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2011-01/102/2008000790/8-
dc.description.srndSEQ:8-
dc.description.srndPERF_CD:SNU2011-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:2008000790-
dc.description.srndADJUST_YN:Y-
dc.description.srndEMP_ID:A079501-
dc.description.srndDEPT_CD:801-
dc.description.srndCITE_RATE:6.314-
dc.description.srndFILENAME:camp and barrier status jid.pdf-
dc.description.srndDEPT_NM:의학과-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2011-01/102/2008000790/8-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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