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analysis of MAST-CLA results as a diagnostic tool in allergic skin diseases

DC Field Value Language
dc.contributor.authorShin, Jung Won-
dc.contributor.authorJin, Seon-pil-
dc.contributor.authorLee, Jong Hee-
dc.contributor.authorCho, Soyun-
dc.creator조소연-
dc.date.accessioned2014-09-02T07:34:15Z-
dc.date.available2014-09-02T07:34:15Z-
dc.date.issued2010-02-
dc.identifier.citationAnnals of Dermatology, Vol.22 No.1, pp. 35-40-
dc.identifier.issn1013-9087-
dc.identifier.urihttps://hdl.handle.net/10371/93005-
dc.description.abstractBackground
Urticaria and atopic dermatitis are representative allergic skin diseases that can be mediated by IgE. Measuring levels of specific IgE can be used to confirm causative agents of these skin diseases.

Objective
To analyze results from the multiple allergosorbent test chemiluminescent assay (MAST-CLA), which measures specific IgE in the presence of a causative agent/allergen, in IgE-mediated skin diseases.

Methods
A total of 404 patients with urticaria, atopic dermatitis or pruritus were enrolled in the present study. Positive rates of specific IgE as well as total serum IgE from the MAST-CLA were compared.

Results
Positive rates of specific IgE were highest in atopic dermatitis patients, followed by urticaria, and then pruritus, with 57.0%, 37.1%, and 20.8%, respectively (p<0.05). House dust mite species were the most common allergens in both atopic dermatitis and urticaria skin diseases. There were no differences in the overall MAST-CLA results between acute and chronic urticaria. The relative positive rate of inhalant allergen was significantly higher in adult than in child atopic dermatitis patients.

Conclusion
Results from the MAST-CLA showed diversity among the three disease groups, and within each disease group, with different positive rates of specific IgE, a different mean allergen number per patient, and so on. Therefore, we concluded that MAST-CLA could be a useful diagnostic tool for various allergic skin diseases.
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dc.language.isokoen
dc.publisherKorean Dermatological Associationen
dc.subject복합학en
dc.subjectAllergen-
dc.subjectAllergic skin diseases-
dc.subjectAtopic dermatitis-
dc.subjectMAST-CLA-
dc.subjectPruritus-
dc.subjectSpecific IgE-
dc.subjectUrticaria-
dc.titleanalysis of MAST-CLA results as a diagnostic tool in allergic skin diseasesen
dc.typeArticle-
dc.contributor.AlternativeAuthor진선필-
dc.contributor.AlternativeAuthor신정원-
dc.contributor.AlternativeAuthor이종희-
dc.contributor.AlternativeAuthor조소연-
dc.identifier.doi10.5021/ad.2010.22.1.35-
dc.description.srndOAIID:oai:osos.snu.ac.kr:snu2010-01/102/2008000790/2-
dc.description.srndSEQ:2-
dc.description.srndPERF_CD:SNU2010-01-
dc.description.srndEVAL_ITEM_CD:102-
dc.description.srndUSER_ID:2008000790-
dc.description.srndADJUST_YN:N-
dc.description.srndEMP_ID:A079501-
dc.description.srndDEPT_CD:801-
dc.description.srndCITE_RATE:.162-
dc.description.srndFILENAME:mast-cla.pdf-
dc.description.srndDEPT_NM:의학과-
dc.description.srndCONFIRM:Y-
dc.identifier.srnd2010-01/102/2008000790/2-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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