S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
- Issue Date
- BioMed Central
- Behavioral and Brain Functions, 10(1) : 43
- This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article,
unless otherwise stated.
- Background: We aimed to determine whether early parenting is associated with externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder (ADHD) and whether such an association is affected by the brain-derived neurotrophic factor (BDNF) val66met polymorphism. Methods: The participants included 92 patients with ADHD aged 6–15 years. Measures of parenting in early life and externalizing and internalizing symptoms and the genotype of the BDNF Val66Met polymorphism were obtained.
Results: The degree to which the babys autonomy was allowed was significantly and negatively correlated with the CDI scores in ADHD children (r = −0.38, p = 0.005). After adjusting for the childs gender, the childs age, the familys gross annual income, and the maternal education level, there was a significant interaction for the BDNF genotype and mothers positive feelings about caring in relation to the development of childhood anxiety/depression in ADHD children (F = 2.51, p = 0.011).
Conclusions: Our results provide evidence of an interaction between the BDNF met allele and early parenting on the development of depression/anxiety symptoms.