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The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder

Cited 5 time in Web of Science Cited 5 time in Scopus
Authors
Park, Subin; Kim, Bung-Nyun; Kim, Jae-Won; Jung, Yeon-Kyung; Lee, Jin; Shin, Min-Sup; Yoo, Hee Jeong; Cho, Soo-Churl
Issue Date
2014-11-25
Publisher
BioMed Central
Citation
Behavioral and Brain Functions, 10(1) : 43
Keywords
BDNFParentingADHD
Description
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article,
unless otherwise stated.
Abstract
Background: We aimed to determine whether early parenting is associated with externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder (ADHD) and whether such an association is affected by the brain-derived neurotrophic factor (BDNF) val66met polymorphism. Methods: The participants included 92 patients with ADHD aged 6–15 years. Measures of parenting in early life and externalizing and internalizing symptoms and the genotype of the BDNF Val66Met polymorphism were obtained.
Results: The degree to which the baby’s autonomy was allowed was significantly and negatively correlated with the CDI scores in ADHD children (r = −0.38, p = 0.005). After adjusting for the child’s gender, the child’s age, the family’s gross annual income, and the maternal education level, there was a significant interaction for the BDNF genotype and mother’s positive feelings about caring in relation to the development of childhood anxiety/depression in ADHD children (F = 2.51, p = 0.011).
Conclusions: Our results provide evidence of an interaction between the BDNF met allele and early parenting on the development of depression/anxiety symptoms.
Language
English
URI
http://hdl.handle.net/10371/93655
DOI
https://doi.org/10.1186/1744-9081-10-43
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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