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Ankyrin Repeat-Rich Membrane Spanning (ARMS)/Kidins220 Scaffold Protein Regulates Neuroblastoma Cell Proliferation through p21
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Heekyung | - |
dc.contributor.author | Shin, Joo-Hyun | - |
dc.contributor.author | Park, Young-Seok | - |
dc.contributor.author | Chang, Mi-Sook | - |
dc.creator | 장미숙 | - |
dc.date.accessioned | 2015-03-11T02:11:41Z | - |
dc.date.available | 2015-03-11T02:11:41Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | Molecules and Cells, Vol.37 No.12, pp. 881-887 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://hdl.handle.net/10371/93959 | - |
dc.description.abstract | Cell proliferation is tightly controlled by the cell-cycle regulatory proteins, primarily by cyclins and cyclin-dependent kinases (CDKs) in the G(1) phase. The ankyrin repeat-rich membrane spanning (ARMS) scaffold protein, also known as kinase D-interacting substrate of 220 kDa (Kidins 220), has been previously identified as a prominent downstream target of neurotrophin and ephrin receptors. Many studies have reported that ARMS/Kidins220 acts as a major signaling platform in organizing the signaling complex to regulate various cellular responses in the nervous and vascular systems. However, the role of ARMS/Kidins220 in cell proliferation and cell-cycle progression has never been investigated. Here we report that knockdown of ARMS/Kidins220 inhibits mouse neuroblastoma cell proliferation by inducing slowdown of cell cycle in the G(1) phase. This effect is mediated by the upregulation of a CDK inhibitor p21, which causes the decrease in cyclin D1 and CDK4 protein levels and subsequent reduction of pRb hyperphosphorylation. Our results suggest a new role of ARMS/Kidins220 as a signaling platform to regulate tumor cell proliferation in response to the extracellular stimuli. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | 자연과학 | en |
dc.title | Ankyrin Repeat-Rich Membrane Spanning (ARMS)/Kidins220 Scaffold Protein Regulates Neuroblastoma Cell Proliferation through p21 | en |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 정희경 | - |
dc.contributor.AlternativeAuthor | 신주현 | - |
dc.contributor.AlternativeAuthor | 박영석 | - |
dc.contributor.AlternativeAuthor | 장미숙 | - |
dc.identifier.doi | 10.14348/molcells.2014.0182 | - |
dc.description.srnd | OAIID:oai:osos.snu.ac.kr:snu2014-01/102/0000027724/2 | - |
dc.description.srnd | SEQ:2 | - |
dc.description.srnd | PERF_CD:SNU2014-01 | - |
dc.description.srnd | EVAL_ITEM_CD:102 | - |
dc.description.srnd | USER_ID:0000027724 | - |
dc.description.srnd | ADJUST_YN:Y | - |
dc.description.srnd | EMP_ID:A075930 | - |
dc.description.srnd | DEPT_CD:852 | - |
dc.description.srnd | CITE_RATE:2.242 | - |
dc.description.srnd | FILENAME:arms-chang-2014.pdf | - |
dc.description.srnd | DEPT_NM:치의과학과 | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | 2014-01/102/0000027724/2 | - |
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