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유행성 Virus간염의 임상상과 간침생검 조직상에 관한 연구 제2편 급성기의 간침생검 조직선에 관한 연구 : STUDIES ON CLINICAL, LABORATORY AND HISTOLOGICAL FINDINGS OF' LIVER BIOPSY IN EPIDEMIC VIRAL HEPATITIS Part II Studies on Histological Findings of Needle Biopsy in Acute Phase
DC Field | Value | Language |
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dc.contributor.author | 정환국 | - |
dc.date.accessioned | 2009-09-16T02:53:53Z | - |
dc.date.available | 2009-09-16T02:53:53Z | - |
dc.date.issued | 1960-06 | - |
dc.identifier.citation | Seoul J Med, Vol.1 No.2, pp. 29-48 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9396 | - |
dc.description.abstract | This studies of infectious hepatitis in inpatients
of the Korean Army cover period of four and half years. between April. 1956 to Sept.. 1960. Serial biopsies have been done at appropriate intervals on 98 out of 143 patients during the acute stage of the 12 weeks after the onset of jaundice. Single bIOpsIes were performed on the remaining 45 cases. Incidence of the histological changes. pathogenesis. histological course and final outcome were studied. The histological picture of hepatitis was compared with the histologic picture of several groups of diseases which produce hepatic damage. Following results were obtained: 1. Bile stasis was noted in the early stages when serum bilirubin was elevated. the stasis was more prominent in the fading stages of jaundice Furthermore an appearance of bile plugs was increased in number during fading stages of jaundice. 2. As the intensity of jaundice increased. the storage of cytoplasmic glycogen decreased. The storage of cytoplasmic glycogen rose again after recovery from jaundice. 3. The peak of inbibition of lipofuscin pigments in liver cells and Kupffer cells was in 4th week after the onset of jaundice. As liver cell necrosis increased, more lipofuscin pigment inbibition was dem9pstrated. 4. Eosinophilic bodies were frequently observed during a month after the onset of jaundice, and during the period, they were seen in a half of the total cases, Ballooning cells were also prominent in this period. 5. Single cell necrosis were peculiar, .and they were seen within 4 weeks after the onset of jaundice. Although the necrosis was noted in the central zone of a lobule in νthe lst,week after the onset of jaundice, it became more extensive in the .4th week. Necrosis in peripheral zones were marked in early stages, and the peak was in the 2nd week after the onset of jaundice. Only 2 cases of massive necrosIs were seen. 6. Mitosis appeared as regenerative phenomena in early part of the 2nd week after the onset of jaundice, multinucleated giant liver cells were noted in the early stages, and multinucleated small liver cells were noted in the later stages. 7. Kupffer cell proliferation was most striking during 2nd and 4th week after the onset of jaundice, and was noted in more than 80% of cases. 8. Inflammatory cellular infiltrations around portal area were chiefly composed of monocytes in the early stages, and lymphocytes in the later stages with an occasional eosinophils and neutrophils. The above picture were prominently observed within one month after the onset of jaundice, and chronic inflammatory mononuclear cells were persistently observed in 77% out of the total cases as late as 3 months after the onset of jaundice. 9. The pictures of bile duct proliferation chiefly around the portal area were seen in later stages, and these pictures persisted in over 60% of cases 2 to 3 months after the onset of jaundice. 10. Fibrosis after hepatitis took place chiefly around the portal area, and its incidence of 11.1% noted in the 1st week after the onset of jaundice, increasing to 70.1% in the 12th week after the onset of jaundice. Post-hepatitic fibrosis was a striking part of the picture. 11. Serial histologic examination revealed that at least 7 weeks were required for complete recovery of severely damaged tissue. However, there was one incidence in which 8 weeks elapsed from severe state to moderate state showing no further recovery. 12. Histologic comparison was carried out with 44 liver biopsy specimens from patients suffering with the following diseases; liver distosomiasls, pulmonary tuberculosis, lobar pneumococcal pneumonia , right sided hemothorax, post-typhoid cholecystitis, passive cardiac congestion of liver, acute bacterial hepatitis, acute cholecystitis and chronic amebic colitis. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 유행성 Virus간염의 임상상과 간침생검 조직상에 관한 연구 제2편 급성기의 간침생검 조직선에 관한 연구 | - |
dc.title.alternative | STUDIES ON CLINICAL, LABORATORY AND HISTOLOGICAL FINDINGS OF' LIVER BIOPSY IN EPIDEMIC VIRAL HEPATITIS Part II Studies on Histological Findings of Needle Biopsy in Acute Phase | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Chung, Whan Kook | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 48 | - |
dc.citation.number | 2 | - |
dc.citation.pages | 29-48 | - |
dc.citation.startpage | 29 | - |
dc.citation.volume | 1 | - |
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