S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 01 No.3 (1960)
저산소증이 관상순환계 혈류량 및 심장근대사에 미치는 영향 : Effects of the Acute Hypoxia on Coronary Flow and Cardiac metabolism
- Issue Date
- 서울대학교 의과대학
- Seoul J Med, Vol.1 No.3, pp. 27-33
- In 6 light nembutalized dogs, hemodynamic study on coronary fow and some metabolic aspects of the heart
were investigated during acute hypoxia which is produced
by 10% oxygen inhalation.
Coronary flow was determined by Kety and Schmidt
s nitrous oxide method. The myocardial extraction or
production rates for 02, C02 and glucose were determined
by measuring A-V differences of each substrate
and coronary flow.
Following results were obtained.
1) Arterial oxygen saturation during acute hypoxia ,
arterial blood pressure, heart rate and respiratory
minute volume were increased , respectively ..
2) The coronary flow was found to be 98cc/min/100
gm. heart 土21. 1 in control and increased to mean of
192cc/min/l00gm. heart±28.5 in the hypoxic state.
3) During hypoxia , myocardial 02 eχtraction was
relatively constant as compared with contro l. Myocardial
C02 production , however , was remarkably decreased.
Therefore, R.Q. in myocardium was found to be 0.9 士
O. 25 in control and O. 67 土0/18 in the hypoxia.
While, glucose extraction of myocardium showed
remarkable increase more than 3 times as compared
with control. These facts showed that myocardial metabolism
in the hypoxia was more anaerobic than in
the contro l.