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부자의 강심작용에 대한 약리학적 검토
Pharmacological Studies on the Cardiotonic Substance from Aconiti tuber

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Authors
박찬웅; 김명석
Issue Date
1981-03
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.22 No.1, pp. 1-14
Abstract
A chloroform insoluble, and n-butanol extractable
fraction from Aconiti tuber has been recently known
to have cardiostimulatory effect. The Aconiti tuber
butanol fraction elicited a potent positive inotropic
effect on the isolated cardiac muscle preparations of
various animals including rat, rabbit and cat. It
increased the rate and the intensity of the developed
isometric tension , while shortened the time from
onset of contraction to peak tension and the total
duration of contraction. In contrast with digitalis
cardiac glycoside , it does not show the animal species
differenee in the positive inotropic effect, and produces
no toxic signs by a 1000 fold concentration of minimal
positive inotropic dose.
In the afterloaded simultaneous isotonic and isorne
tric contraction of cat papillary muscle , Aconiti tuber
butanol fraction increased the maximal velocity of
shortening and the maximal developed force , however
it had no appreciable influence on the properties of
the series elastic component of the muscle contractile
model.
The excitability of the isolated rabbit atrium increased
slightly at low concentration(•:;x 1O- ' g/ml) ,
while decreased at higher concentration, and the
refractory period of right atrium was slightly prolonged
at 2 x 10-3g/ml.
Analyzing the relation of the positive inotropic
effect of Aconiti tuber butanol fraction to the frequency
of contraction, more powerful inotropic effect
was produced at shorter stimulation interval. The
cumulated positive inotropic effect of activation
(PIEA) and the amount of PIEA produced by each
contraction increased significantly with the higher
stimulation frequency either
In contrast to digitalis cardiac glycoside , Aconiti
tuber butanol fraction did not show potassium dcpendency
in the positive inotropic effect. It produced
almost same increment of isometric tension and elF/
dt at varying concentrations of extracellular patassium.
However, the dependency of the inotropic effect
of Aconiti tuber on the extracellular calcium has been
observed , and a synergistic or additive action could
be demonstrated between two substances.
Aconiti tuber butanol fraction in concentration of
10-7 -10-2g/ml does not seem to have direct eficct
on either the cardiac contractile proteins or ATP ase
of actomyosin, but the membrane bound Na-K-ATPase
activity was markedly inhibited in the usual inotropic
concentrations.
In anesthetized rabbit, heart rate and left γentricular
pressure were reduced by Aconiti tuber butanol fraction.
It caused a slight and variable incrcase in
cardiac out-put and carotid blood flow, but systemic
arterial pressure decreased in a dose-dependent mannero
ISSN
0582-6802
Language
Korean
URI
https://hdl.handle.net/10371/9471
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 22 No.1 (1981)
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