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악성종양환자의 혈액응고양상에 관한 연구
Blood coagulation studies in patients with cancer

DC Field Value Language
dc.contributor.author박명희-
dc.date.accessioned2009-09-16T07:07:45Z-
dc.date.available2009-09-16T07:07:45Z-
dc.date.issued1981-06-
dc.identifier.citationSeoul J Med, Vol.22 No.2, pp. 271-288-
dc.identifier.issn0582-6802-
dc.identifier.urihttps://hdl.handle.net/10371/9503-
dc.description.abstractA study of hemostatic abnormalities in 102 randomly
selected cancer patients was undertaken t()
evaluate the overall incidence and types of bemostatic
derangements in these patients by 15 coagulation
tests.
The results are as follows:
L Majority of the patients showed one or more
abnormal coagulation tests and two thirds had four
or more abnormal results. Most common abnormalities
were hyperfibrinogenemia (62%) and prolonged serial thromhin time (61%) followed by elevated factor
VIII (45%) and VII (38%) , elevated FDP (36%)
and decreased antithrombin III (28%) levels in
decreasing order of frequency.
2. Patients with distant metastases (53%) more
frequently had elevated FDP level compared to those
without distant metastases (8%).
Patients with elevated FDP level showed much
higher frequency of prolonged prothrombin time,
positive protamine sulfate test and decreased antithrombin
III level compared to those with normal
FDP level.
Majority of the patients with increased FDP level
showed laboratory features of compensated or
overcompensated intravascular coagulation and
fibrinolysis.
3. Patients with hepatoma revealed marked abnormalities
in coagulation tests, and compared to
patients with other types of cancer these patients
showed significantly high frequency of prolonged
prothrombin time as well as decreased factor II,
elevated FDP, prolonged thrombin time, thrombocytopenia
and decreased antithrombin III in addition
to markedly increased factor VIII level; these abnormaIities
were considered to be manifestations of
underlying liver cirrhosis. Hepatoma patients without
underlying liver cirrhosis showed normal or elevated
platelet count, fibrinogen and factor VII, whereas
these were markedly decreased in two thirds of the
control patients with liver cirrhosis.
4. Patients with stomach cancer had significantly
shortened prothrombin time and activated partial
thromboplastin time compared to normal controls.
and these findings along with markedly elevated
fibrinogen, factor VII and VIII suggested hypercoagulability
of blood. However about 30% of the
patients had abnormally shortened euglobulin lysis
time, representing features of increased fibrinolysis.
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dc.language.isoko-
dc.publisher서울대학교 의과대학-
dc.title악성종양환자의 혈액응고양상에 관한 연구-
dc.title.alternativeBlood coagulation studies in patients with cancer-
dc.typeSNU Journal-
dc.contributor.AlternativeAuthorPark, Myoung Hee-
dc.citation.journaltitle서울 의대 잡지-
dc.citation.journaltitle서울 의대 학술지-
dc.citation.journaltitleSeoul Journal of Medicine-
dc.citation.endpage288-
dc.citation.number2-
dc.citation.pages271-288-
dc.citation.startpage271-
dc.citation.volume22-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 22 No.2 (1981)
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