태아 고환의 성숙과정에 관한 관찰

Abstract

To evaluate the maturing process of male gonad during intrauterine life , a morphologic study was made, based on 135 normal human fetuses ranging in age from 16 to 40 gestation weeks. These fetuses were the products of induced deliveries, and were found to have no associated diseases or congenital anormalies at autopsy. Following observations were made: 1. Cross diameter of fetal testis increased as the fetus2S approached the term. There were two strueturally different periods during fetal dεvelopment: ene was rapid phase that lasted from 16th to 22nd week of gestation, and the other was slow phase that was from the 23rd to 40 weeks of gestational age. 2. The interstitial cells became prominent during the perioid of the 16th to 20th week of gestation and did rapidly disappear thereafter. 3. Mean diameter of seminiferous tubules decreased from G8.3μ at the 16th week to 55.5t at the 21th week and to 49. 0μ by term 4. Approximate ratio of spermatogonium to total cells in seminiferous tubules \vere 18.7"-'23.9% throughout the entire fetal period examined. E type spermatogonia were generally dominant campanεnt and A type spermatogonia appeared to decrease in number as the fetuses reached the term. 5. The tunica albuginea was incompletely formed and measured 40μ in thickness at the 16th week. It became progressively stabilized and thickened to be 210μ at the 34th week and 240{, by term. G. The rete testis communicated with seminiferous tubules by abortive lumens at the 16th 까re c k and became completely matured by 32 weeks of age. 7. There were 5 cases of ectopic adrenal glands embedded in testis among 1:13 cases, thus showing an incidence of 3.7%. 8. Based on above observations it could be concludcd as that first evidence of maturation as a male testis in fetal period was seen at tlF~ 24th week of gestation, thereafter it became slowly and progressi~ vely matured to show adult type histology except for spermatogenesis, by the 31th week of 앙 c s t a t lO n .