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Efficacy of a Topical Gelatin-Thrombin Matrix Sealant in Reducing Postoperative Drainage Following Anterior Cervical Discectomy and Fusion

Cited 2 time in Web of Science Cited 3 time in Scopus
Authors
Li, Quan You; Lee, Osung; Han, Ho Sung; Kim, Gang-Un; Lee, Chee Kean; Kang, Sung Shik; Lee, Myung Ho; Cho, Hyeon Guk; Kim, Ho-Joong; Yeom, Jin S.
Issue Date
2015
Publisher
Korean Society of Spine Surgery
Citation
Asian Spine Journal, vol.9 no.6, pp. 909-915
Keywords
Cervical vertebraeHemostasisPostoperative hemorrhageFloseal matrixSpinal fusion
Description
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/)
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Study Design
Retrospective fusion level(s)-, age-, and gender-matched analysis.

Purpose
To determine whether the application of a topical gelatin-thrombin matrix sealant (Floseal) at the end of anterior cervical discectomy and fusion (ACDF) can reduce the amount of postoperative hemorrhage.

Overview of Literature
The effect of the matrix sealant in decreasing postoperative hemorrhage following ACDF has not been reported.

Methods
Matrix sealant was (n=116, study group) or was not applied (n=58, control group) at the end of ACDF. Patients were selected by 1:2 matching criteria of fusion level(s), age, and gender. Seven parameters described below were compared between the two groups.

Results
The total drain amount for the first 24 hours (8±9 versus 27±22 mL), total drain amount until the 8-hour drainage decreased to ≤10 mL (8±10 versus 33±26 mL), and the total drain amount until 6 AM on the first postoperative day (7±8 versus 24±20 mL) were significantly lower in the study group than the control group (all p<0.001). The time for the 8-hour drainage to decrease to ≤10 mL was significantly lower in the study group (10±5 versus 26±14 hours, p<0.001). The 8-hour drainage decreased to ≤10 mL on the operation day in most patients (88%) in the study group versus mostly on the first (48%) or second (33%) postoperative day in the control group (p<0.001). The total drain amount until 6 AM on the first postoperative day was 0 mL in 43% of patients in the study group and in 7% in the control group (p<0.001). No patient in either group required hematoma evacuation.

Conclusions
Application of the topical matrix sealant at the end of ACDF can significantly reduce the amount of postoperative hemorrhage.
Language
English
URI
http://hdl.handle.net/10371/95429
DOI
https://doi.org/10.4184/asj.2015.9.6.909
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College of Medicine/School of Medicine (의과대학/대학원)Orthopedic Surgery (정형외과학전공)Journal Papers (저널논문_정형외과학전공)
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