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Anti-biofouling Coating by Wrinkled, Dual-roughness Structures of Diamond-like Carbon (DLC)

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dc.contributor.authorRahmawan, Yudi-
dc.contributor.authorJang, Kyung-Jin-
dc.contributor.authorMoon, Myoung-Woon-
dc.contributor.authorLee, Kwang-Ryeol-
dc.contributor.authorSuh, Kahp-Yang-
dc.date.accessioned2009-09-16T10:28:12Z-
dc.date.available2009-09-16T10:28:12Z-
dc.date.issued2009-06-20-
dc.identifier.citationBiochip J. 3, 143-150, 2009en
dc.identifier.issn1976-0280-
dc.identifier.urihttp://biochips.or.kr/-
dc.identifier.urihttps://hdl.handle.net/10371/9556-
dc.description.abstractThe textured surface with superhydrophobic nature was explored for an anti-biofouling template. Hierarchical structures composed of the nano-scale wrinkle covering on micro-scale polymer pillar patterns were fabricated by combining the deposition of a thin coating layer of biocompatible diamond-like carbon (DLC) and the replica molding of poly-(dimethylsiloxane) (PDMS) micro-pillars. The as-prepared surfaces were shown to have extreme hydrophobicity (static contact angle > 160 degrees) owing to low surface energy (24.2 mN/m) and dual-roughness structures of the DLC coating. It was explored that the hierarchical surfaces showed poor adhesion of the Calf Pulmonary Artery Endothelial (CPAE) cells for cultures of 7 days suggesting that the 3-dimensional (3-D) patterned superhydrophobic DLC coating exhibits excellent anti-biofouling properties against non-specific cell adhesion. In particular, the reduced filopodia extension during cell growth was caused by disconnected focal adhesions on the pillar pattern. This limited cell adhesion could prevent undesired growth and proliferation of biological species on the surface of biomedical devices such as stents, implants or even injection syringes.en
dc.description.sponsorshipThis work was supported by Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (MOST) (R01-2007-000-20675-0), the Micro Thermal System Research Center of Seoul National University, and the Korea Research Foundation Grant funded by the Korean Government (MOEHRD) (Grant KRF-J03003). This work was supported in part by a grant (06K1501-01610) from the CNMT under the 21st Century Frontier R&D Programs
of MEST of Korea (MWM, KRL).
en
dc.language.isoen-
dc.publisher한국바이오칩학회 = The Korean BioChip Societyen
dc.relation.ispartofseries3 (2)en
dc.relation.ispartofseries143-150en
dc.subjectDiamond-Like Carbon (DLC)en
dc.subjectCell adhesionen
dc.subjectSuperhydrophobicityen
dc.subjectSuperhydrophobicityen
dc.subjectDual-scale structureen
dc.subjectAnti-biofoulingen
dc.subjectCORONARY-ARTERY DISEASEen
dc.subjectBALLOON ANGIOPLASTYen
dc.subjectSOFT LITHOGRAPHYen
dc.subjectSURFACEen
dc.subjectSTENTen
dc.subjectRESTENOSISen
dc.subjectENERGYen
dc.subjectPREVENTIONen
dc.subjectPROTEINSen
dc.subjectADHESIONen
dc.titleAnti-biofouling Coating by Wrinkled, Dual-roughness Structures of Diamond-like Carbon (DLC)en
dc.typeArticleen
dc.contributor.AlternativeAuthor장경진-
dc.contributor.AlternativeAuthor문명원-
dc.contributor.AlternativeAuthor이광렬-
dc.contributor.AlternativeAuthor서갑양-
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Mechanical Aerospace Engineering (기계항공공학부)Journal Papers (저널논문_기계항공공학부)
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