담관계 결석 관련요인에 관한 연구

Abstract

Though stones in biliary tree are the common disease in Korea, known as stomachache or chestache" for laymen, reliable morbidity have not been reported until recently. Most of biliary calculi could be cured only by means of surgical modality, If some re asonable risk factors could be found and effective preventive measures available, those will be of great value to the improvement of health and lessening the patients financial burden. The mechanism of biliary calculi formation is still not known exactly but the pattern of disease seems to be influenced not only by geographical location but also by living habits. For example, with respect to location of calculi, in contrast to the fact that gallbladder stone presents more than 9096 of total biliary calculi cases in America and Europe, gallbladder stone is estimated to be less than 50% of cases in Korea. Instead, common bile duct and intrahepatic stone accounts for 40% to 70% of total cases So the risk factors related to biliary calculi in Korea might be different to that in America and Europe, and some attributes such as living habits and environment may play important roles to gallst~ 。n e disease Therefore, as an initial attempt to figure out the factors to gallstone in Korea , a case'control study on risk factors is conducted with 121 cases of gallstone and 205 cases of control patients Comparison of some selected attributes such as sex, age, body weight and height, educational back ground,socioeconomic status, and clinical laboratory findings as serum cholesterol, blood hemoglobin, serurn protein, fasting blood sugar, is made between case group by the location of stones and control group patients. Also, chemical analyses of the stones obtained from 30 cases out of 121 stone pat:ents were carried out using gas chromatography. And the res ults of chemical analyses were compared according to the location. The results and findings obtained in this study suggest that the dietary habit certainly is one of the causal factors of biliary calculi. The diet related to obesity and diabetes is more prone to cause gall~ bladder stones compared to common bile duct and intrahepatic stones which are probably provoked by lowcalory and low protein constitution