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한국인 태아 소뇌의 형태학적 발육에 관한 연구 : Studies on Morphological Development of the Human Fetal Cerebellum
DC Field | Value | Language |
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dc.contributor.author | 황용승 | - |
dc.date.accessioned | 2009-09-16T10:51:12Z | - |
dc.date.available | 2009-09-16T10:51:12Z | - |
dc.date.issued | 1984-06 | - |
dc.identifier.citation | Seoul J Med, Vol.25 No.2, pp. 209-229 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9570 | - |
dc.description.abstract | To evaluate the morphological development of cerebellum
76 specimens of Korean human fetal cerebel 1um were studied. The fetuses were products of artificial abortion with the gestational age from 15 to 40 weeks , and were proved to be normal after complete examination of fetuses and placentas. The weight of cerebellum and dimensions of anteroposterior diame' ter , transverse diameter and height of cerebellum were measured. Blocks were taken from 5 different areas of hemisphere and vermis and analyzed under light microscope. The weight of cerebellum increased steadily by gestational age with a surge at 25~28 weeks of gestation and reached 7.6% of the total brain weight by term. The measurements of cerebellum also increased steadily with the gestational age, and the trans verse diameter increased more rapidly than the height of the cerebellum. Grossly the surface of the cerebellum revealed characteristic features by the appearance of posterolateral and primary fissures and foliation. The foliation became δrst noted at the vermis and then was followed by anterior and posterior lobes of the hemispheres. Histological development of cerebellar cortex was more progressive in vermis than in hemispheres, anterior or posterior lobe, in genera l. The number of cell rows and thickness of the external granular layer decreased at the term of gestation. The thickness of molecular layer increased in the vermis and in the posterior lobe of hemisphere from 29~32 weeks and 33~36 weeks of gestation, respectively, but it showed no significant change in the anterior lobe of hemisphere. The Purl이nje cell became morphologically mature by 33~36 weeks of gestation in the vermis , although there was a 4 weeks lag in the hemisphere. During the period of active development the density of Purkinje cells at the bottom of sulcus was greater than that at the top of gyrus. Lamina dissecans was a transient structure that was recognized after 21~24 weeks of gestation and disappeared by 29~32 weeks of gestation. The disap pearance of lamina dissecans in the vermis was earlier than that in the region of hemisphere. The number of cell rows and thickness of the internal granular layer of the developing cerebellar cortex could not be seperated from the underlying white matter during 13~20 weeks of gestation in the anterior and posterior lobes of hemisphere although it could be recognized during 13~20 weeks at the region of the vermis. The number of cell rows and thickness of internal granular layer increased rapidly after 29~32 weeks of gestation in both hemispheres and vermis. Comparing the development of the top of gyrus and that of the bottom of sulcus, it was apparent that the number of cell rows and the thickness of external granular layer at the bottom of sulcus were greater than those at the top of gyrus , whereas the number of cell rows and the thickness of internal granular layer at the top of gyrus were greater than those at the bottom of sulcus. These observations were regarded as a mechanism of formation of cereh ellar folia | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 한국인 태아 소뇌의 형태학적 발육에 관한 연구 | - |
dc.title.alternative | Studies on Morphological Development of the Human Fetal Cerebellum | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Hwang, Yong Seung | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 229 | - |
dc.citation.number | 2 | - |
dc.citation.pages | 209-229 | - |
dc.citation.startpage | 209 | - |
dc.citation.volume | 25 | - |
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