Publications
Detailed Information
Steroid Hormone 투여에 의하여 유기된 낭성신병변의 초미세구조학적 특성에 관한 실험적 연구 : Ultrastructural Observations of Steroid Hormone-Induced Cystic Disease of the Kidney in Newborn Rabbits
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김석희 | - |
dc.contributor.author | 김영균 | - |
dc.date.accessioned | 2009-09-16T11:42:37Z | - |
dc.date.available | 2009-09-16T11:42:37Z | - |
dc.date.issued | 1984-09 | - |
dc.identifier.citation | Seoul J Med, Vol.25 No.3, pp. 430-442 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9596 | - |
dc.description.abstract | Cystic disease of the kidney was induced in the
newborn white rabbits by a single intramuscular inj· ection of prednisolone crystalline (50mg/kg) , cortisone acetate (200mg/kg) , dexamethasone (40mg/kg) , methylprednisolone acetate (20mg/kg) , and their conventional light microscopic and ultrastructural changes were constructed to understand the morphogenesis and the sequential evolution of cystic lesions 1. Cystic lesions were induced only in the perinatal rabbits by injection of methylprednisolone acetate (MPA) and dexamethasone, and not by prednisolone crystalline or cortisone acetate. All pregnant animals with MPA injection resulted in total failure by abor' tion. 2. Cystic lesions were predominantly located in the renal cortex, and consisted of 2 major types; the tubular cyst of proximal and collecting tubular origin in the early phase, and the glomerular cyst of diIat· ation of Bowmans urinary space in the latcr phase. 3. Tubular dilatation was most profound at the 3rd week after injection and showed a tendency of reduction thereafter. On the contrary, the glomerular cysts developed with increasing tendency from the 4th week. 4. Cystic dilatation of the proximal and collecting tubules was more prominent in rabbits with prolongation of perinatal period of nephrogenic activity in the renal cortex; there were also morphological evid ences of interlesional continuity between the nephrogenic vesicle or S-shaped bodies and cystic structures. 5. Ultrastructurally poor development ef microvilli of proximal tubules, numerical decrease and irregula· rity of intracytoplasmic organelles, and delayed development of baso-Iateral infoldings were all indicative of maturation arrest, and also were associated with uneven thickening of tubular basement membrane together with lamellation, fraying and rarefaction With the above findings it is the author's assumption that steroid hormone, especially MPA may result in maturation arrest of nephrogenic activity in the perinataI renal cortex, and its cystic evolution is closely correlated with alteration of tublar basement membrane during the period of nephrogenic activity. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | Steroid Hormone 투여에 의하여 유기된 낭성신병변의 초미세구조학적 특성에 관한 실험적 연구 | - |
dc.title.alternative | Ultrastructural Observations of Steroid Hormone-Induced Cystic Disease of the Kidney in Newborn Rabbits | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Kim, Suk Hee | - |
dc.contributor.AlternativeAuthor | Kim, Young Kyoon | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 442 | - |
dc.citation.number | 3 | - |
dc.citation.pages | 430-442 | - |
dc.citation.startpage | 430 | - |
dc.citation.volume | 25 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.