알레르기성 비염에서의 스테로이드 비내주사의 효과에 관한연구

Abstract

The treatment of perennial allergic rhinitis is often unsatisfactory. Of the conventional drugs antihistamines may cause unacceptable somnolence and decongestant nasal drop often produce a rebound exacerbation of allergic symptoms after prolonged use. Intranasal sodium cromoglycate (Cohan et aI., 1976), however, is helpful in many patients and systemi c steroid therapy is effective but its use for long periods in patients whose symptoms are incon venient rather than life threatening is rarely jus tified. Clinical studies have demonstrated the effectiveness of submucosal injection of steroid solution in the treatment of perennial allergic rhinitis due to a variety of offending allergens (Simmons, 1960). Baker & Strauss, 1962; Mowart, 1961; Mabry, 1978; McGrew et aI., 1978; Although the effectiveness and safety of submucosal injection of steroid has been tried in the treatment of perennial allergic rhinitis, there is very little literature in the way of double-blind clinical trials. This double-blind trial was started in February, 1984 and was completed in June , 1984 with 26 cases of perennial allergic rhinitis which were confirmed by history, clinical examinations, laboratory tests and skin test. This study was designed to determine if submucosal injection of steroid solution would significantly improve the allergic symptoms in a group of patients with perennial allergic rhinitis.