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Rapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal region

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dc.contributor.authorPark, Seong Hoe-
dc.contributor.authorShin, Young Kee-
dc.contributor.authorSuh, Young Ho-
dc.contributor.authorPark, Won Seo-
dc.contributor.authorBan, Young Larn-
dc.contributor.authorChoi, Hueng-Sik-
dc.contributor.authorPark, Hyo Jin-
dc.contributor.authorJung, Kyeong Cheon-
dc.date.accessioned2009-09-23T09:20:29Z-
dc.date.available2009-09-23T09:20:29Z-
dc.date.issued2005-06-28-
dc.identifier.citationGene 353, 177-188en
dc.identifier.issn0378-1119-
dc.identifier.urihttp://hdl.handle.net/10371/9700-
dc.description.abstractThe human pseudoautosomal region 1 (PAR1) is essential for the obligatory X-Y crossover in male meiosis. Despite its critical role, comparative studies of human and mouse pseudoautosomal genes have been limited owing to the scarcity of genes conserved between the two species. Human CD99 is a 32-kDa cell surface protein that is encoded by the MIC2 gene localized to the PAR1. Although several sequences such as CD99L2, PBDX, and CD99L1 are related to CD99, its murine ortholog, Cd99, has not yet been identified. Here we report a novel mouse Cd99, designated D4, which shows overall sequence homology to CD99, with the highest conservation between the two genes being found in the transmembrane regions. In addition, the D4 protein displays biochemical characteristics, functional homology, and expression patterns similar to those of CD99. The D4 gene is localized on an autosome, chromosome 4, reflecting a common mapping feature with other mouse orthologs of human PAR1 genes. Furthermore, a phylogenetic analysis of CD99-related genes confirmed that the D4 gene is indeed an ortholog of CD99 and exhibits the accelerated evolution pattern of CD99 orthologs, as compared to the CD99L2 orthologs. On the basis of these findings, we suggest that CD99 belongs to the ancient PAR genes, and that the rapid interspecies divergence of its present sequence and map position is due to a high recombination frequency and the occurrence of chromosomal translocation, supporting the addition-attrition hypothesis for PAR evolution.en
dc.description.sponsorshipWe thank Im-Soon Lee (Department of Biological
Sciences, Konkuk University, Korea) for critical review of
this manuscript. This work was supported in part by a
research grant (#M1010400012401J00000551) of National
Research Laboratory Program from Korea Ministry of
Science and Technology and the 02’ DiNonA Inc. R&D
Project, Seoul, Korea.
en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectCD99, MIC2en
dc.subjectPseudoautosomalen
dc.subjectHomologyen
dc.subjectOrthologen
dc.subjectPhylogeneticen
dc.titleRapid divergency of rodent CD99 orthologs: implications for the evolution of the pseudoautosomal regionen
dc.typeArticleen
dc.contributor.AlternativeAuthor박성회-
dc.contributor.AlternativeAuthor신영기-
dc.contributor.AlternativeAuthor서영호-
dc.contributor.AlternativeAuthor박원서-
dc.contributor.AlternativeAuthor반영란-
dc.contributor.AlternativeAuthor최형식-
dc.contributor.AlternativeAuthor박효진-
dc.contributor.AlternativeAuthor정경천-
dc.identifier.doi10.1016/j.gene.2005.04.023-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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