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Cervical lymph node metastases: MR imaging of gadofluorine M and monocrystalline iron oxide nanoparticle-47 in a rabbit model of head and neck cancer
DC Field | Value | Language |
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dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Han, Moon Hee | - |
dc.contributor.author | Moon, Woo Kyung | - |
dc.contributor.author | Son, Kyu Ri | - |
dc.contributor.author | Won, Jae-Kyung | - |
dc.contributor.author | Kim, Ji-Hoon | - |
dc.contributor.author | Kwon, Bae Ju | - |
dc.contributor.author | Na, Dong Gyu | - |
dc.contributor.author | Weinmann, Haans-Joachim | - |
dc.contributor.author | Chang, Kee-Hyun | - |
dc.date.accessioned | 2009-09-26T05:04:56Z | - |
dc.date.available | 2009-09-26T05:04:56Z | - |
dc.date.issued | 2006-10-13 | - |
dc.identifier.citation | Radiology 2006;241:753–762 | en |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.uri | https://hdl.handle.net/10371/9888 | - |
dc.description.abstract | Purpose: To prospectively compare the accuracy of gadofluorine M with that of monocrystalline iron oxide nanoparticle (MION)-47 for the depiction of cervical lymph node metastases at magnetic resonance (MR) imaging in a rabbit model of head and neck cancer by using histologic analysis as the reference standard.
Materials and Methods: Experiments were approved by the animal care committee. VX2 carcinomas were implanted in both ears of 11 rabbits 4 weeks before MR imaging. T2-weighted, T2*-weighted, and T1-weighted MR images were acquired, and sequential T1-weighted MR imaging was performed immediately and 30 minutes after administration of gadofluorine M (0.05 mmol gadolinium per kilogram body weight). T2-weighted and T2*-weighted MR imaging were performed 24 hours after administration of MION-47 (2.6 mg iron per kilogram body weight). Gadofluorine M– and MION-47–enhanced MR imaging were performed separately and independently by two radiologists who had no knowledge of histopathologic results, and the presence of metastases in lymph nodes was evaluated. A receiver operating characteristic analysis was conducted to compare the diagnostic value of gadofluorine M– and MION-47–enhanced MR imaging. Results: Metastases were confirmed in 20 of 77 lymph nodes at histopathologic analysis. The area under the curve was significantly greater for gadofluorine M–enhanced MR imaging (0.997 and 0.981 for readers 1 and 2, respectively) than for MION-47–enhanced MR imaging (0.889 and 0.846 for readers 1 and 2, respectively). For gadofluorine M–enhanced MR imaging, sensitivity was 100% for both readers and specificity was 89.5% for reader 1 and 87.7% for reader 2. For MION-47–enhanced MR imaging, sensitivity was 80.0% for both readers and specificity was 75.4% for reader 1 and 71.9% for reader 2. Conclusion: Gadofluorine M–enhanced MR imaging has higher accuracy for depicting lymph node metastases than does MION-47–enhanced MR imaging. | en |
dc.language.iso | en | - |
dc.publisher | Radiological Society of North America (RSNA) | en |
dc.title | Cervical lymph node metastases: MR imaging of gadofluorine M and monocrystalline iron oxide nanoparticle-47 in a rabbit model of head and neck cancer | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최승홍 | - |
dc.contributor.AlternativeAuthor | 한문희 | - |
dc.contributor.AlternativeAuthor | 문우경 | - |
dc.contributor.AlternativeAuthor | 손규리 | - |
dc.contributor.AlternativeAuthor | 원재경 | - |
dc.contributor.AlternativeAuthor | 김지훈 | - |
dc.contributor.AlternativeAuthor | 권배주 | - |
dc.contributor.AlternativeAuthor | 나동규 | - |
dc.contributor.AlternativeAuthor | 장기현 | - |
dc.identifier.doi | 10.1148/radiol.2413051979 | - |
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