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Showing results 1 to 60 of 78

Issue Date	Title / Author(s) / Citation	File
2011-03	Chungtaejeon, a Korean Fermented Tea, Scavenges Oxidation and Inhibits Cytokine Induced Proliferation and Migration of Human Aortic Smooth Muscle Cells Karki, Rajendra; Sahi, Navin; Jeon, Eun-Raye; Park, Yong-Seo; Kim, Dong-Wook Plant Foods for Human Nutrition, Vol.66 No.1, pp.27-33	DOI
2012-02	Inhibitory Effect of Nelumbo nucifera (Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice Karki, Rajendra; Jung, Myung-A; Kim, Keuk-Jun; Kim, Dong-Wook Evidence-based Complementary and Alternative Medicine, Vol.2012, p. 153568	DOI
2012-03	Magnoliae Cortex inhibits intimal thickening of carotid artery through modulation of proliferation and migration of vascular smooth muscle cells Karki, Rajendra; Jeon, Eun-Raye; Kim, Dong-Wook Food and Chemical Toxicology, Vol.50 No.3-4, pp.634-640	DOI
2013-01	Nelumbo nucifera leaf extract inhibits neointimal hyperplasia through modulation of smooth muscle cell proliferation and migration Karki, Rajendra; Jeon, Eun-Raye; Kim, Dong-Wook Nutrition, Vol.29 No.1, pp.268-275	DOI
2013-03	Magnolol attenuates neointima formation by inducing cell cycle arrest via inhibition of ERK1/2 and NF-κB activation in vascular smooth muscle cells Karki, Rajendra; Ho, Oak-Min; Kim, Dong-Wook Biochimica et Biophysica Acta - General Subjects, Vol.1830 No.3, pp.2619-2628	DOI
2013-07	Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7) Karki, Rajendra; Park, Cheol-Ho; Kim, Dong-Wook Journal of Integrative Medicine, Vol.11 No.4, pp.246-252	DOI
2013-09	Toll-Like Receptor 4–Mediated Nuclear Factor Kappa B Activation Is Essential for Sensing Exogenous Oxidants to Propagate and Maintain Oxidative/Nitrosative Cellular Stress Karki, Rajendra; Igwe, Orisa J. PLoS ONE, Vol.8 No.9, p. e73840	DOI
2013-12	Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation Karki, Rajendra; Kim, Seong-Bin; Kim, Dong-Wook Experimental Cell Research, Vol.319 No.20, pp.3238-3250	DOI
2014-06	Activation of c-Src: A hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling Karki, Rajendra; Zhang, Yan; Igwe, Orisa J. Free Radical Biology and Medicine, Vol.71, pp.256-269	DOI
2015-03	Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection Karki, Rajendra; Man, Si Ming; Malireddi, R. K. Subbarao; Gurung, Prajwal; Vogel, Peter; Lamkanfi, Mohamed; Kanneganti, Thirumala-Devi Cell Host and Microbe, Vol.17 No.3, pp.357-368	DOI
2015-03	An NLRP3 inflammasome–triggered Th2-biased adaptive immune response promotes leishmaniasis Gurung, Prajwal; Karki, Rajendra; Vogel, Peter; Watanabe, Makiko; Bix, Mark; Lamkanfi, Mohamed; Kanneganti, Thirumala-Devi Journal of Clinical Investigation, Vol.125 No.3, pp.1329-1338	DOI
2015-05	The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection Man, Si Ming; Karki, Rajendra; Malireddi, R. K. Subbarao; Neale, Geoffrey; Vogel, Peter; Yamamoto, Masahiro; Lamkanfi, Mohamed; Kanneganti, Thirumala-Devi Nature Immunology, Vol.16 No.5, pp.467-475	DOI
2015-07	Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer Man, Si Ming; Zhu, Qifan; Zhu, Liqin; Liu, Zhiping; Karki, Rajendra; Malik, Ankit; Sharma, Deepika; Li, Liyuan; Malireddi, R. K. Subbarao; Gurung, Prajwal; Neale, Geoffrey; Olsen, Scott R.; Carter, Robert A.; McGoldrick, Daniel J.; Wu, Gang; Finkelstein, David; Vogel, Peter; Gilbertson, Richard J.; Kanneganti, Thirumala-Devi Cell, Vol.162 No.1, pp.45-58	DOI
2015-11	Toll-like receptor 4 signaling: A common pathway for interactions between prooxidants and extracellular disulfide high mobility group box 1 (HMGB1) protein-coupled activation Zhang, Yan; Karki, Rajendra; Igwe, Orisa J. Biochemical Pharmacology, Vol.98 No.1, pp.132-143	DOI
2016-02	AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity Man, Si Ming; Karki, Rajendra; Kanneganti, Thirumala-Devi European Journal of Immunology, Vol.46 No.2, pp.269-280	DOI
2016-05	Alkaloid rich fraction from Nelumbo nucifera targets VSMC proliferation and migration to suppress restenosis in balloon-injured rat carotid artery Jun, Moon Young; Karki, Rajendra; Paudel, Keshav Raj; Sharma, Bhesh Raj; Adhikari, Deepak; Kim, Dong-Wook Atherosclerosis, Vol.248, pp.179-189	DOI
2016-06	DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota Man, Si Ming; Karki, Rajendra; Kanneganti, Thirumala-Devi Pathogens and Disease, Vol.74 No.4, p. ftw028	DOI
2016-08	Cepharanthine inhibits in vitro VSMC proliferation and migration and vascular inflammatory responses mediated by RAW264.7 Paudel, Keshav Raj; Karki, Rajendra; Kim, Dong-Wook Toxicology in Vitro, Vol.34, pp.16-25	DOI
2016-08	ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways Kuriakose, Teneema; Man, Si Ming; Malireddi, R. K. Subbarao; Karki, Rajendra; Kesavardhana, Sannula; Place, David E.; Neale, Geoffrey; Vogel, Peter; Kanneganti, Thirumala-Devi Science immunology, Vol.1 No.2, p. aag2045	DOI
2016-09	Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection Qi, Xiaopeng; Man, Si Ming; Malireddi, R. K. Subbarao; Karki, Rajendra; Lupfer, Christopher; Gurung, Prajwal; Neale, Geoffrey; Guy, Clifford S.; Lamkanfi, Mohamed; Kanneganti, Thirumala-Devi Journal of Experimental Medicine, Vol.213 No.10, pp.2081-2097	DOI
2016-09	Phytochemical profile and biological activity of Juglans regia Panth, Nisha; Paudel, Keshav Raj; Karki, Rajendra Journal of Integrative Medicine, Vol.14 No.5, pp.359-373	DOI
2016-10	IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes Man, Si Ming; Karki, Rajendra; Sasai, Miwa; Place, David E.; Kesavardhana, Sannula; Temirov, Jamshid; Frase, Sharon; Zhu, Qifan; Malireddi, R. K. Subbarao; Kuriakose, Teneema; Peters, Jennifer L.; Neale, Geoffrey; Brown, Scott A.; Yamamoto, Masahiro; Kanneganti, Thirumala-Devi Cell, Vol.167 No.2, pp.382-396.e17	DOI
2016-12	IL-33 regulates the IgA-microbiota axis to restrain IL-1α–dependent colitis and tumorigenesis Malik, Ankit; Sharma, Deepika; Zhu, Qifan; Karki, Rajendra; Guy, Clifford S.; Vogel, Peter; Kanneganti, Thirumala-Devi Journal of Clinical Investigation, Vol.126 No.12, pp.4469-4481	DOI
2016-12	NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer Karki, Rajendra; Man, Si Ming; Malireddi, R. K. Subbarao; Kesavardhana, Sannula; Zhu, Qifan; Burton, Amanda R.; Sharma, Bhesh Raj; Qi, Xiaopeng; Pelletier, Stephane; Vogel, Peter; Rosenstiel, Philip; Kanneganti, Thirumala-Devi Nature, Vol.540 No.7634, pp.583-587	DOI
2017-01	A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development Sharma, Bhesh Raj; Gautam, Lekh Nath S.; Adhikari, Deepak; Karki, Rajendra Phytotherapy Research, Vol.31 No.1, pp.3-26	DOI
2017-02	Inflammasomes and Cancer Karki, Rajendra; Man, Si Ming; Kanneganti, Thirumala-Devi Cancer immunology research, Vol.5 No.2, pp.94-99	DOI
2017-03	Differential roles of caspase-1 and caspase-11 in infection and inflammation Man, Si Ming; Karki, Rajendra; Briard, Benoit; Burton, Amanda; Gingras, Sebastien; Pelletier, Stephane; Kanneganti, Thirumala-Devi Scientific Reports, Vol.7, p. 45126	DOI
2017-05	Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases Man, Si Ming; Karki, Rajendra; Kanneganti, Thirumala-Devi Immunological Reviews, Vol.277 No.1, pp.61-75	DOI
2017-06	NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer Karki, Rajendra; Malireddi, R. K. Subbarao; Zhu, Qifan; Kanneganti, Thirumala-Devi Cell Cycle, Vol.16 No.13, pp.1243-1251	DOI
2018-03	Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection Zhu, Qifan; Man, Si Ming; Karki, Rajendra; Malireddi, R. K. Subbarao; Kanneganti, Thirumala-Devi Cell Reports, Vol.22 No.12, pp.3168-3174	DOI
2018-03	Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis Sharma, Deepika; Malik, Ankit; Guy, Clifford S.; Karki, Rajendra; Vogel, Peter; Kanneganti, Thirumala-Devi Gastroenterology, Vol.154 No.4, pp.948-964.e8	DOI
2018-04	ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming Place, David E.; Samir, Parimal; Karki, Rajendra; Briard, Benoit; Vogel, Peter; Kanneganti, Thirumala-Devi American Journal of Pathology, Vol.188 No.4, pp.1021-1030	DOI
2018-05	Phytochemical profile and pharmacological activity of Aegle marmelos Linn Manandhar, Bikash; Paudel, Keshav Raj; Sharma, Biraj; Karki, Rajendra Journal of Integrative Medicine, Vol.16 No.3, pp.153-163	DOI
2018-05	The NLRC4 inflammasome requires IRF8-dependent production of NAIPs Lee, Ein; Karki, Rajendra; Kanneganti, Thirumala-Devi Cell Stress, Vol.2 No.6, pp.144-146	DOI
2018-05	IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation Karki, Rajendra; Lee, Ein; Place, David; Samir, Parimal; Mavuluri, Jayadev; Sharma, Bhesh Raj; Balakrishnan, Arjun; Malireddi, R. K. Subbarao; Geiger, Rechel; Zhu, Qifan; Neale, Geoffrey; Kanneganti, Thirumala-Devi Cell, Vol.173 No.4, pp.920-933.e13	DOI
2018-06	Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa Balakrishnan, Arjun; Karki, Rajendra; Berwin, Brent; Yamamoto, Masahiro; Kanneganti, Thirumala-Devi Cell Death Discovery, Vol.4, p. 66	DOI
2018-12	Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida Zhu, Qifan; Zheng, Min; Balakrishnan, Arjun; Karki, Rajendra; Kanneganti, Thirumala-Devi Journal of Immunology, Vol.201 No.12, pp.3662-3668	DOI
2019-01	Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging Luo, Hanzhi; Mu, Wei-Chieh; Karki, Rajendra; Chiang, Hou-Hsien; Mohrin, Mary; Shin, Jiyung J.; Ohkubo, Rika; Ito, Keisuke; Kanneganti, Thirumala-Devi; Chen, Danica Cell Reports, Vol.26 No.4, pp.945-954.e4	DOI
2019-02	Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection Briard, Benoit; Karki, Rajendra; Malireddi, R. K. Subbarao; Bhattacharya, Anannya; Place, David E.; Mavuluri, Jayadev; Peters, Jennifer L.; Vogel, Peter; Yamamoto, Masahiro; Kanneganti, Thirumala-Devi Nature Microbiology, Vol.4 No.2, pp.316-327	DOI
2019-04	Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice Sharma, Bhesh Raj; Karki, Rajendra; Lee, Ein; Zhu, Qifan; Gurung, Prajwal; Kanneganti, Thirumala-Devi Cell Death and Differentiation, Vol.26 No.4, pp.741-750	DOI
2019-04	Diverging inflammasome signals in tumorigenesis and potential targeting Karki, Rajendra; Kanneganti, Thirumala-Devi Nature Reviews Cancer, Vol.19 No.4, pp.197-214	DOI
2019-09	DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome Samir, Parimal; Kesavardhana, Sannula; Patmore, Deanna M.; Gingras, Sebastien; Malireddi, R. K. Subbarao; Karki, Rajendra; Guy, Clifford S.; Briard, Benoit; Place, David E.; Bhattacharya, Anannya; Sharma, Bhesh Raj; Nourse, Amanda; King, Sharon V.; Pitre, Aaron; Burton, Amanda R.; Pelletier, Stephane; Gilbertson, Richard J.; Kanneganti, Thirumala-Devi Nature, Vol.573 No.7775, pp.590-594	DOI
2019-11	Role of AIM2 inflammasome in inflammatory diseases, cancer and infection Sharma, Bhesh Raj; Karki, Rajendra; Kanneganti, Thirumala-Devi European Journal of Immunology, Vol.49 No.11, pp.1998-2011	DOI
2020-03	Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion Place, David E.; Briard, Benoit; Samir, Parimal; Karki, Rajendra; Bhattacharya, Anannya; Guy, Clifford S.; Peters, Jennifer L.; Frase, Sharon; Vogel, Peter; Neale, Geoffrey; Yamamoto, Masahiro; Kanneganti, Thirumala-Devi PLoS Pathogens, Vol.16 No.3, p. e1008364	DOI
2020-03	The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis Dasari, Tejasvi K.; Geiger, Rechel; Karki, Rajendra; Banoth, Balaji; Sharma, Bhesh Raj; Gurung, Prajwal; Burton, Amanda; Kanneganti, Thirumala-Devi Journal of Biological Chemistry, Vol.295 No.11, pp.3394-3400	DOI
2020-04	Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense Zheng, Min; Karki, Rajendra; Vogel, Peter; Kanneganti, Thirumala-Devi Cell, Vol.181 No.3, pp.674-687.e13	DOI
2020-05	Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) Christgen, Shelbi; Zheng, Min; Kesavardhana, Sannula; Karki, Rajendra; Malireddi, R. K. Subbarao; Banoth, Balaji; Place, David E.; Briard, Benoit; Sharma, Bhesh Raj; Tuladhar, Shraddha; Samir, Parimal; Burton, Amanda; Kanneganti, Thirumala-Devi Frontiers in cellular and infection microbiology, Vol.10, p. 237	DOI
2020-05	IRF8 Regulates Gram-Negative Bacteria–Mediated NLRP3 Inflammasome Activation and Cell Death Karki, Rajendra; Lee, Ein; Sharma, Bhesh R.; Banoth, Balaji; Kanneganti, Thirumala-Devi Journal of Immunology, Vol.204 No.9, pp.2514-2522	DOI
2020-06	Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer Karki, Rajendra; Sharma, Bhesh Raj; Lee, Ein; Banoth, Balaji; Malireddi, R. K. Subbarao; Samir, Parimal; Tuladhar, Shraddha; Mummareddy, Harisankeerth; Burton, Amanda R.; Vogel, Peter; Kanneganti, Thirumala-Devi JCI insight, Vol.5 No.12, p. e136720	DOI
2020-10	Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection Zheng, Min; Williams, Evan Peter; Malireddi, R. K. Subbarao; Karki, Rajendra; Banoth, Balaji; Burton, Amanda; Webby, Richard; Channappanavar, Rudragouda; Jonsson, Colleen Beth; Kanneganti, Thirumala-Devi Journal of Biological Chemistry, Vol.295 No.41, pp.14040-14052	DOI
2020-12	ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis) Banoth, Balaji; Tuladhar, Shraddha; Karki, Rajendra; Sharma, Bhesh Raj; Briard, Benoit; Kesavardhana, Sannula; Burton, Amanda; Kanneganti, Thirumala-Devi Journal of Biological Chemistry, Vol.295 No.52, pp.18276-18283	DOI
2020-12	RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis Subbarao, Malireddi R.K.; Kesavardhana, Sannula; Karki, Rajendra; Kancharana, Balabhaskararao; Burton, Amanda R.; Kanneganti, Thirumala-Devi ImmunoHorizons, Vol.4 No.12, pp.789-796	DOI
2020-12	Galactosaminogalactan activates the inflammasome to provide host protection Briard, Benoit; Fontaine, Thierry; Samir, Parimal; Place, David E.; Muszkieta, Laetitia; Malireddi, R. K. Subbarao; Karki, Rajendra; Christgen, Shelbi; Bomme, Perrine; Vogel, Peter; Beau, Remi; Mellado, Emilia; Ibrahim-Granet, Oumaima; Henrissat, Bernard; Kalathur, Ravi C.; Robinson, Cam; Latge, Jean-Paul; Kanneganti, Thirumala-Devi Nature, Vol.588 No.7839, pp.688-692	DOI
2021-01	DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response Kesavardhana, Sannula; Samir, Parimal; Zheng, Min; Malireddi, R. K. Subbarao; Karki, Rajendra; Sharma, Bhesh Raj; Place, David E.; Briard, Benoit; Vogel, Peter; Kanneganti, Thirumala-Devi Journal of Biological Chemistry, Vol.296, p. 100579	DOI
2021-01	Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes Karki, Rajendra; Sharma, Bhesh Raj; Tuladhar, Shraddha; Williams, Evan Peter; Zalduondo, Lillian; Samir, Parimal; Zheng, Min; Sundaram, Balamurugan; Banoth, Balaji; Malireddi, R. K. Subbarao; Schreiner, Patrick; Neale, Geoffrey; Vogel, Peter; Webby, Richard; Jonsson, Colleen Beth; Kanneganti, Thirumala-Devi Cell, Vol.184 No.1, pp.149-168.e17	DOI
2021-01	Liensinine Prevents Vascular Inflammation by Attenuating Inflammatory Mediators and Modulating VSMC Function Jun, Moon Young; Karki, Rajendra; Paudel, Keshav Raj; Panth, Nisha; Devkota, Hari Prasad; Kim, Dong-Wook APPLIED SCIENCES-BASEL, Vol.11 No.1	DOI
2021-07	Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth Malireddi, R.K. Subbarao; Karki, Rajendra; Sundaram, Balamurugan; Kancharana, Balabhaskararao; Lee, SangJoon; Samir, Parimal; Kanneganti, Thirumala-Devi ImmunoHorizons, Vol.5 No.7, pp.568-580	DOI
2021-07	Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation Tartey, Sarang; Gurung, Prajwal; Karki, Rajendra; Burton, Amanda; Hertzog, Paul; Kanneganti, Thirumala-Devi Cellular and Molecular Immunology, Vol.18 No.7, pp.1798-1808	DOI
2021-07	TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines Zheng, Min; Karki, Rajendra; Williams, Evan Peter; Yang, Dong; Fitzpatrick, Elizabeth; Vogel, Peter; Jonsson, Colleen Beth; Kanneganti, Thirumala-Devi Nature Immunology, Vol.22 No.7, pp.829-838	DOI
2021-08	The 'cytokine storm': molecular mechanisms and therapeutic prospects Karki, Rajendra; Kanneganti, Thirumala-Devi Trends in Immunology, Vol.42 No.8, pp.681-705	DOI

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