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Local tumor invasiveness is more predictive of survival than International Prognostic Index in stage I(E)/II(E) extranodal NK/T-cell lymphoma, nasal type

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Authors
Kim, Tae Min; Park, Yeon Hee; Lee, Sang-Yoon; Kim, Ji-Hoon; Kim, Dong-Wan; Im, Seock-Ah; Kim, Tae-You; Kim, Chul Woo; Heo, Dae Seog; Bang, Yung-Jue; Chang, Kee-Hyun; Kim, Noe Kyeong
Issue Date
2005-08-20
Publisher
American Society of Hematology
Citation
Blood. 2005;106:3785-3790
Keywords
AdolescentAdultAge FactorsAgedAntineoplastic Combined Chemotherapy Protocols/therapeutic useDisease-Free SurvivalHumansKiller Cells, Natural/pathologyLymphoma, T-Cell/*mortality/pathology/therapyMaleMiddle Aged*Neoplasm Invasiveness*Neoplasm StagingNose Neoplasms/*mortality/pathology/therapyPrognosisRadiotherapyRemission InductionSurvival AnalysisSurvival Rate
Abstract
This study was launched to determine the prognostic significance of local tumor invasiveness (LTI) in 114 patients diagnosed with stage I(E)/II(E) extranodal natural killer (NK)/T-cell lymphoma, nasal type (NTCL). LTI was defined as bony invasion or destruction or tumor invasion of the skin. Complete remission (CR), overall survival (OS), and disease-free survival (DFS) were compared between each group according to LTI, Ann Arbor stage, and International Prognostic Index (IPI). LTI was observed in 23 patients. Using multivariate analysis, factors associated with low probability of CR were the presence of LTI (P < .001), the presence of B symptoms (P = .003), and single-modality chemotherapy (P = .045). The presence of LTI (relative risk [RR] = 8.4, 95% confidence interval [CI] 3.9-17.9; P < .001) and high IPI score (RR = 2.8, 95% CI 1.2-6.8; P = .019) were also predictive of OS. The presence of LTI (RR = 7.3, 95% CI 3.2-16.5; P < .001) was an independently significant factor for reduced DFS. Ann Arbor staging system did not predict CR, OS, or DFS but IPI did have predictive power with regard to survival outcome. LTI is the most important prognostic factor in predicting low probability of CR and reduced OS and DFS in nasal stage I(E)/II(E) NTCL.
ISSN
0006-4971 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16109779

http://hdl.handle.net/10371/10003
DOI
https://doi.org/10.1182/blood-2005-05-2056
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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