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Age-related changes in microvillar cells of rat olfactory epithelium

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dc.contributor.authorKwon, Bum Sun-
dc.contributor.authorKim, Min Kyu-
dc.contributor.authorKim, Woo Ho-
dc.contributor.authorPyo, Jung-Soo-
dc.contributor.authorCheon, Young Hee-
dc.contributor.authorCha, Choong Ik-
dc.contributor.authorNam, Seon Young-
dc.contributor.authorBaik, Tai-Kyoung-
dc.contributor.authorLee, Byung Lan-
dc.date.accessioned2009-10-01T05:59:34Z-
dc.date.available2009-10-01T05:59:34Z-
dc.date.issued2005-03-19-
dc.identifier.citationNeurosci. Lett. 378 (2005) 65-69.en
dc.identifier.issn0304-3940 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15774259-
dc.identifier.urihttp://hdl.handle.net/10371/10022-
dc.description.abstractThe nature and function of microvillar cells (MVCs) of the mammalian olfactory epithelium (OE) are little understood. Previous studies have examined MVC morphology in the developing and mature OE, but not in the aged OE. The present study investigated the effect of aging on MVCs of the OE in male Sprague-Dawley rats using histological and immunohistochemical methods. OE of aged rats contained MVCs with marked hypertrophy and swollen end-feet, which reached the basement membrane. Such MVC features were not observed in the young OE. These MVC changes were more conspicuous in proximity to severely degenerated olfactory receptor neurons (ORNs) and supporting cells. The ratio of the number of MVCs to that of supporting cells increased with aging; however, MVCs in the aged OE were not proliferating cell nuclear antigen-immunoreactive. In addition, the total cell population was decreased in the aged OE. Thus, our results suggest that MVCs are non-neuronal and that they are more resistant to aging compared to ORNs and supporting cells.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAge Factorsen
dc.subjectAging/*physiologyen
dc.subjectAnimalsen
dc.subjectCell Count/methodsen
dc.subjectCell Sizeen
dc.subjectEpithelial Cells/physiology/*ultrastructureen
dc.subjectGlial Fibrillary Acidic Protein/metabolismen
dc.subjectHypertrophy/pathologyen
dc.subjectImmunohistochemistry/methodsen
dc.subjectMaleen
dc.subjectMicroscopy, Electron, Transmission/methodsen
dc.subjectMicrovilli/ultrastructureen
dc.subjectOlfactory Mucosa/metabolism/*physiology/ultrastructureen
dc.subjectProliferating Cell Nuclear Antigen/metabolismen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.titleAge-related changes in microvillar cells of rat olfactory epitheliumen
dc.typeArticleen
dc.contributor.AlternativeAuthor권범선-
dc.contributor.AlternativeAuthor김민규-
dc.contributor.AlternativeAuthor김우호-
dc.contributor.AlternativeAuthor표정수-
dc.contributor.AlternativeAuthor전영희-
dc.contributor.AlternativeAuthor차중익-
dc.contributor.AlternativeAuthor남선영-
dc.contributor.AlternativeAuthor백태경-
dc.contributor.AlternativeAuthor이병란-
dc.identifier.doi10.1016/j.neulet.2004.11.094-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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