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Germ cells and transgenesis in chickens

Cited 72 time in Web of Science Cited 78 time in Scopus
Authors
Han, Jae Yong
Issue Date
2009
Publisher
Elsevier
Citation
Comparative Immunology, Microbiology and Infectious Diseases, vol.32 no.2, pp. 61-80
Keywords
Transgenic chickenPrimordial germ cellsGermline stem cellsModel animalBioreactor
Abstract
Chickens have proven to be useful organisms for transgenic research. This work provides enormous benefits in advancing animal biotechnology and aids in the development of unique technologies for bioreactor production and experimental model development. The various advantages of chicken transgenesis are derived from the genetic and physiological characteristics of this organism, although several physiological properties have impeded the development of an efficient transgenic system. We have developed embryo-mediated and testis-mediated transgenic systems using chicken primordial germcells (PGCs) from embryos and testicular cells from adult males. These methods are efficient and involve minimal technical effort. Here, we review previous transgenic research using PGCs and testicular cells fromchickens. Furthermore, wehave summarized the development of the chickenmodel system in biomedical science and biotechnology and our recent achievements in this field.
ISSN
0147-9571
Language
English
URI
http://hdl.handle.net/10371/100274
DOI
https://doi.org/10.1016/j.cimid.2007.11.010
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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