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Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jong Woo | - |
dc.contributor.author | Soung, Young Hwa | - |
dc.contributor.author | Kim, Su Young | - |
dc.contributor.author | Nam, Hyo Kyung | - |
dc.contributor.author | Park, Won Sang | - |
dc.contributor.author | Nam, Suk Woo | - |
dc.contributor.author | Kim, Min Sik | - |
dc.contributor.author | Sun, Dong Il | - |
dc.contributor.author | Lee, Youn Soo | - |
dc.contributor.author | Jang, Ja June | - |
dc.contributor.author | Lee, Jung Young | - |
dc.contributor.author | Yoo, Nam Jin | - |
dc.contributor.author | Lee, Sug Hyung | - |
dc.date.accessioned | 2009-10-04T22:32:15Z | - |
dc.date.available | 2009-10-04T22:32:15Z | - |
dc.date.issued | 2005-04-15 | - |
dc.identifier.citation | Clin Cancer Res 2005;11:2879-82. | en |
dc.identifier.issn | 1078-0432 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15837736 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10030 | - |
dc.description.abstract | PURPOSE: Recently, the kinase domain mutations of epidermal growth factor receptor (EGFR) gene have been identified in non-small-cell lung cancer, and these mutations have been related to the clinical response to the tyrosine kinase inhibitor gefitinib. Gefitinib treatment has also shown clinical benefits in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to explore the possibility that SCCHN harbored the EGFR mutations. EXPERIMENTAL DESIGN: In this study, we analyzed EGFR gene in 41 SCCHN for the detection of the somatic mutations by PCR-single-strand conformational polymorphism analysis. RESULTS: Overall, we detected three EGFR mutations (7.3%), and all of the mutations were the same in-frame deletion mutation in exon 19 (E746_A750del). CONCLUSION: These data indicated that in addition to non-small-cell lung cancer, SCCHN harbors the EGFR gene mutations, and suggested the rationale for the clinical applicability of gefinitib to SCCHN patients. | en |
dc.language.iso | en | en |
dc.publisher | American Association for Cancer Research | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Base Sequence | en |
dc.subject | Carcinoma, Squamous Cell/*genetics | en |
dc.subject | DNA Mutational Analysis | en |
dc.subject | DNA, Neoplasm/chemistry/genetics | en |
dc.subject | Female | en |
dc.subject | Head and Neck Neoplasms/*genetics | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Single-Stranded Conformational | en |
dc.subject | Receptor, Epidermal Growth Factor/*genetics | en |
dc.subject | Mutation | - |
dc.title | Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이종우 | - |
dc.contributor.AlternativeAuthor | 김수영 | - |
dc.contributor.AlternativeAuthor | 남효경 | - |
dc.contributor.AlternativeAuthor | 박원상 | - |
dc.contributor.AlternativeAuthor | 남석우 | - |
dc.contributor.AlternativeAuthor | 김민식 | - |
dc.contributor.AlternativeAuthor | 선동일 | - |
dc.contributor.AlternativeAuthor | 이연수 | - |
dc.contributor.AlternativeAuthor | 장자준 | - |
dc.contributor.AlternativeAuthor | 이정영 | - |
dc.contributor.AlternativeAuthor | 유남진 | - |
dc.contributor.AlternativeAuthor | 이석형 | - |
dc.identifier.doi | 10.1158/1078-0432.CCR-04-2029 | - |
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