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Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients
DC Field | Value | Language |
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dc.contributor.author | Chen, Duo | - |
dc.contributor.author | Wen, Xianyu | - |
dc.contributor.author | Song, Young Seok | - |
dc.contributor.author | Rhee, Ye-Young | - |
dc.contributor.author | Lee, Tae Hun | - |
dc.contributor.author | Cho, Nam Yun | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.date.accessioned | 2017-02-06T01:38:42Z | - |
dc.date.available | 2017-02-06T01:38:42Z | - |
dc.date.issued | 2016-04-05 | - |
dc.identifier.citation | Clinical Epigenetics, 8(1):36 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100420 | - |
dc.description | This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | ko_KR |
dc.description.abstract | Abstract
Background Low methylation status of LINE-1 in tumors is associated with poor survival in patients with colon cancer. Eastern Cooperative Oncology Group performance status (ECOG-PS) is a method to assess the functional status of a patient. We retrospectively evaluated the relationship between ECOG-PS and LINE-1 methylation in colorectal cancers (CRCs) and their prognostic impact in CRC or colon cancer patients receiving adjuvant 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX). Results LINE-1 methylation and microsatellite instability were analyzed in stage III or high-risk stage II CRCs (n = 336). LINE-1 methylation levels were correlated with clinicopathological features, including PS and recurrence-free survival (RFS). The association between the tumoral LINE-1 methylation level and PS was observed (OR = 2.56, P < 0.001). Differences in LINE-1 methylation levels in cancer tissue between the PS 0 and 1 groups were significant in patients older than 60years (P = 0.001), the overweight body mass index group (P = 0.005), and the stage III disease group (P = 0.008). Prognostic significances of LINE-1 methylation status or combined PS and LINE-1 methylation statuses were identified in stage III colon cancers, not in stage III and high-risk stage II CRCs. Low LINE-1 methylation status was closely associated with a shorter RFS time. The difference between PS(0)/LINE-1(high) and PS(≥1)/LINE-1(low) was significant, which suggests that colon cancer patients with concurrent PS(≥1)/LINE-1 (low) have a higher recurrence rate. Conclusions PS was associated with LINE-1 methylation in CRC tissue. LINE-1 methylation was associated with RFS in stage III colon cancer patients who were treated with adjuvant FOLFOX chemotherapy. Combined PS and LINE-1 methylation status might serve as a useful predictor of cancer recurrence. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Adjuvant therapy | ko_KR |
dc.subject | Colorectal cancer | ko_KR |
dc.subject | ECOG | ko_KR |
dc.subject | FOLFOX | ko_KR |
dc.subject | LINE-1 | ko_KR |
dc.subject | Methylation | ko_KR |
dc.subject | Prognosis | ko_KR |
dc.title | Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 송영석 | - |
dc.contributor.AlternativeAuthor | 이예영 | - |
dc.contributor.AlternativeAuthor | 이태훈 | - |
dc.contributor.AlternativeAuthor | 조남윤 | - |
dc.contributor.AlternativeAuthor | 한새원 | - |
dc.contributor.AlternativeAuthor | 김태유 | - |
dc.contributor.AlternativeAuthor | 강경훈 | - |
dc.identifier.doi | 10.1186/s13148-016-0203-8 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Chen et al. | - |
dc.date.updated | 2017-01-06T09:58:21Z | - |
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