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Germline modification and engineering in avian species
Cited 13 time in
Web of Science
Cited 15 time in Scopus
- Authors
- Issue Date
- 2015
- Publisher
- Springer
- Citation
- Molecules and Cells, vol.38 no.9, pp. 743-749
- Keywords
- avian ; germline competent cell ; germline modification ; genome editing
- Description
- This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To
view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
- Abstract
- Production of genome-edited animals using germline-competent cells and genetic modification tools has provided opportunities for investigation of biological mechanisms in various organisms. The recently reported programmed genome editing technology that can induce gene modification at a target locus in an efficient and precise manner facilitates establishment of animal models. In this regard, the demand for genome-edited avian species, which are some of the most suitable model animals due to their unique embryonic development, has also increased. Furthermore, germline chimera production through long-term culture of chicken primordial germ cells (PGCs) has facilitated research on production of genome-edited chickens. Thus, use of avian germline modification is promising for development of novel avian models for research of disease control and various biological mechanisms. Here, we discuss recent progress in genome modification technology in avian species and its applications and future strategies.
- ISSN
- 1016-8478
- Language
- English
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