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Putative type 1 thymidylate synthase and dihydrofolate reductase as signature genes of a novel bastille-like group of phages in the subfamily Spounavirinae

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dc.contributor.authorAsare, Paul Tetteh-
dc.contributor.authorJeong, Tae-Yong-
dc.contributor.authorRyu, Sangryeol-
dc.contributor.authorKlumpp, Jochen-
dc.contributor.authorLoessner, Martin J.-
dc.contributor.authorMerrill, Bryan D.-
dc.contributor.authorKim, Kwang-Pyo-
dc.date.accessioned2017-02-07T05:40:44Z-
dc.date.available2017-02-07T05:40:44Z-
dc.date.issued2015-08-07-
dc.identifier.citationBMC Genomics, 16(1):582ko_KR
dc.identifier.urihttp://hdl.handle.net/10371/100477-
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a
link to the Creative Commons license, and indicate if changes were made.
ko_KR
dc.description.abstractAbstract

Background

Spounavirinae viruses have received an increasing interest as tools for the control of harmful bacteria due to their relatively broad host range and strictly virulent phenotype.


Results
In this study, we collected and analyzed the complete genome sequences of 61 published phages, either ICTV-classified or candidate members of the Spounavirinae subfamily of the Myoviridae. A set of comparative analyses identified a distinct, recently proposed Bastille-like phage group within the Spounavirinae. More importantly, type 1 thymidylate synthase (TS1) and dihydrofolate reductase (DHFR) genes were shown to be unique for the members of the proposed Bastille-like phage group, and are suitable as molecular markers. We also show that the members of this group encode beta-lactamase and/or sporulation-related SpoIIIE homologs, possibly questioning their suitability as biocontrol agents.


Conclusions
We confirm the creation of a new genus—the “Bastille-like group”—in Spounavirinae, and propose that the presence of TS1- and DHFR-encoding genes could serve as signatures for the new Bastille-like group. In addition, the presence of metallo-beta-lactamase and/or SpoIIIE homologs in all members of Bastille-like group phages makes questionable their suitability for use in biocontrol.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectSpounavirinaeko_KR
dc.subjectThymidylate synthaseko_KR
dc.subjectDihydrofolate reductaseko_KR
dc.subjectBastille-like groupko_KR
dc.subjectBacteriophagesko_KR
dc.titlePutative type 1 thymidylate synthase and dihydrofolate reductase as signature genes of a novel bastille-like group of phages in the subfamily Spounavirinaeko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor정태용-
dc.contributor.AlternativeAuthor류상렬-
dc.contributor.AlternativeAuthor김광표-
dc.identifier.doi10.1186/s12864-015-1757-0-
dc.language.rfc3066en-
dc.rights.holderAsare et al.-
dc.date.updated2017-01-06T10:06:21Z-
Appears in Collections:
College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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