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Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study

Cited 9 time in Web of Science Cited 5 time in Scopus
Authors
Park, Minseon; So, Rina; Joo, Kwon Wook; Yoon, Hyung-Jin
Issue Date
2016-01-06
Publisher
BioMed Central
Citation
BMC Nephrology, 17(1):3
Keywords
Chronic kidney diseaseGlomerular filtration rateMetabolic acidosisRenal hyperfiltrationSerum bicarbonate
Description
This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made.
Abstract
Abstract

Background
Lower serum bicarbonate, mainly due to the modern Western-style diet, and renal hyperfiltration (RHF) are both independently associated with higher mortality in the general population with preserved renal function. The objective of this study was to evaluate the association between serum bicarbonate and RHF.


Methods
The health data of 41,886 adults with an estimated glomerular filtration rate (eGFR) ≥60 mL/min per 1.73 m2 were analyzed. The eGFR was calculated with the Chronic Kidney Disease Epidemiology Collaboration creatinine equation and RHF was defined as eGFR with adjusted residuals > sex-specific 95th percentile.


Results
The adjusted mean of eGFR was lower in the highest quintile of serum bicarbonate than in other quintiles, after adjusting for confounders. A lower percentile rank of serum bicarbonate was associated with higher odds of RHF. The odds ratio (OR) for RHF in the lowest quintile of serum bicarbonate was 1.39 (95 % confidence interval, 95 % CI, 1.11–1.75) compared to the highest, after adjusting for confounders. With subgroup analysis, the association was prominent in participants with a body mass index >25 kg/m2 (OR 1.98, 95 % CI 1.32–2.95 in the lowest quintile compared to the highest), compared to those with a body mass index ≤25 kg/m2 (OR 1.18, 95 % CI 0.89–1.56 in the lowest quintile compared to the highest).


Conclusions
This study observed an association between lower serum bicarbonate and higher odds of RHF and the possible differential effect of obesity in this association. It is necessary to confirm the association between lower serum bicarbonate and RHF and its causality.
Language
English
URI
http://hdl.handle.net/10371/100571
DOI
https://doi.org/10.1186/s12882-015-0218-y
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College of Medicine/School of Medicine (의과대학/대학원)Biomedical Engineering (의공학전공)Journal Papers (저널논문_의공학전공)
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